In Vitro Gene Delivery By Degraded Polyamidoamine Dendrimers

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In Vitro Gene Delivery by Degraded Polyamidoamine Dendrimers

    https://pubs.acs.org/doi/10.1021/bc9600630
    Transfection of cultured cells has been reported using complexes between DNA and spherical cationic polyamidoamine polymers (Starburst dendrimers) that consist of primary amines on the surface and tertiary amines in the interior. The transfection activity of the dendrimers is dramatically enhanced (>50-fold) by heat treatment in a variety of solvolytic solvents, e.g., water or butanol. Such ...Author: Mary X. Tang, Carl T. Redemann, Francis C. Szoka

In vitro gene delivery by degraded polyamidoamine dendrimers.

    https://www.ncbi.nlm.nih.gov/pubmed/8950489
    In vitro gene delivery by degraded polyamidoamine dendrimers. Tang MX(1), Redemann CT, Szoka FC Jr. Author information: (1)School of Pharmacy, University of California, San Francisco 94143-0446, USA.Author: Mary X. Tang, Carl T. Redemann, Francis C. Szoka

In Vitro Gene Delivery by Degraded Polyamidoamine Dendrimers

    https://pubs.acs.org/doi/full/10.1021/bc9600630
    Transfection of cultured cells has been reported using complexes between DNA and spherical cationic polyamidoamine polymers (Starburst dendrimers) that consist of primary amines on the surface and tertiary amines in the interior. The transfection activity of the dendrimers is dramatically enhanced (>50-fold) by heat treatment in a variety of solvolytic solvents, e.g., water or butanol.Author: Mary X. Tang, Carl T. Redemann, Francis C. Szoka

Polyamidoamine dendrimers as gene delivery carriers in the ...

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3440688/
    Depending on their characteristics, such as a high efficiency in delivery, the capability of specific targeting, multifunctionality, biodegradability, non-toxicity, non-immunogenicity and the capability of limiting DNA degradation, nanovectors, such as polyamidoamine (PAMAM) dendrimers for cellular gene delivery, provide a promising approach to ...

Activated and non-activated PAMAM dendrimers for gene ...

    https://www.sciencedirect.com/science/article/pii/S1549963409000094
    Activated and non-activated PAMAM dendrimers for gene delivery in vitro and in vivo. ... In vitro gene delivery by degraded polyamidoamine dendrimers. Bioconjug Chem, 7 (1996), pp. 703-714 ... In vitro gene delivery using polyamidoamine dendrimers with a trimesyl core.Author: Gemma Navarro, Conchita Tros de ILarduya

In vitro gene delivery by degraded polyamidoamine ...

    http://europepmc.org/abstract/MED/8950489
    Jan 01, 1996 · Dendrimers with defective branching have been synthesized and also have improved transfection activity compared to that of the intact dendrimers. For a series of heat-treated dendrimers we observe a correlation between transfection activity and the degree of flexibility, computed with a random cleavage simulation of the degradation process.Author: Mary X. Tang, Carl T. Redemann, Francis C. Szoka

Dendrimers in gene delivery - ScienceDirect

    https://www.sciencedirect.com/science/article/pii/S0169409X05001936
    2. Dendrimers. Since their conception in the late 1970s and early 1980s the unique properties of dendrimers have spawned a whole range of new research areas ranging from drug and gene delivery applications to processing, diagnostics, and nanoengineering .. In comparison to the traditional polymers that initiated a materials revolution in the second half of the last century, dendrimers are ...Author: Christine Dufès, Ijeoma F. Uchegbu, Andreas G. Schätzlein

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