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https://pubs.acs.org/doi/10.1021/bc9600630
Transfection of cultured cells has been reported using complexes between DNA and spherical cationic polyamidoamine polymers (Starburst dendrimers) that consist of primary amines on the surface and tertiary amines in the interior. The transfection activity of the dendrimers is dramatically enhanced (>50-fold) by heat treatment in a variety of solvolytic solvents, e.g., water or butanol. Such ...Author: Mary X. Tang, Carl T. Redemann, Francis C. Szoka
https://www.ncbi.nlm.nih.gov/pubmed/8950489
In vitro gene delivery by degraded polyamidoamine dendrimers. Tang MX(1), Redemann CT, Szoka FC Jr. Author information: (1)School of Pharmacy, University of California, San Francisco 94143-0446, USA.Author: Mary X. Tang, Carl T. Redemann, Francis C. Szoka
https://pubs.acs.org/doi/full/10.1021/bc9600630
Transfection of cultured cells has been reported using complexes between DNA and spherical cationic polyamidoamine polymers (Starburst dendrimers) that consist of primary amines on the surface and tertiary amines in the interior. The transfection activity of the dendrimers is dramatically enhanced (>50-fold) by heat treatment in a variety of solvolytic solvents, e.g., water or butanol.Author: Mary X. Tang, Carl T. Redemann, Francis C. Szoka
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3440688/
Depending on their characteristics, such as a high efficiency in delivery, the capability of specific targeting, multifunctionality, biodegradability, non-toxicity, non-immunogenicity and the capability of limiting DNA degradation, nanovectors, such as polyamidoamine (PAMAM) dendrimers for cellular gene delivery, provide a promising approach to ...
https://www.sciencedirect.com/science/article/pii/S1549963409000094
Activated and non-activated PAMAM dendrimers for gene delivery in vitro and in vivo. ... In vitro gene delivery by degraded polyamidoamine dendrimers. Bioconjug Chem, 7 (1996), pp. 703-714 ... In vitro gene delivery using polyamidoamine dendrimers with a trimesyl core.Author: Gemma Navarro, Conchita Tros de ILarduya
http://europepmc.org/abstract/MED/8950489
Jan 01, 1996 · Dendrimers with defective branching have been synthesized and also have improved transfection activity compared to that of the intact dendrimers. For a series of heat-treated dendrimers we observe a correlation between transfection activity and the degree of flexibility, computed with a random cleavage simulation of the degradation process.Author: Mary X. Tang, Carl T. Redemann, Francis C. Szoka
https://www.sciencedirect.com/science/article/pii/S0169409X05001936
2. Dendrimers. Since their conception in the late 1970s and early 1980s the unique properties of dendrimers have spawned a whole range of new research areas ranging from drug and gene delivery applications to processing, diagnostics, and nanoengineering .. In comparison to the traditional polymers that initiated a materials revolution in the second half of the last century, dendrimers are ...Author: Christine Dufès, Ijeoma F. Uchegbu, Andreas G. Schätzlein
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