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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165193/
Jun 01, 2014 · An in situ gel was formulated for ocular delivery of ofloxacin, using carbopol and hydroxypropyl methylcellulose (HPMC). The latter was used to impart the viscosity to the carbopol solution, while reducing its acidity . On the other hand, an aqueous solution of carbopol-HPMC system was designed and developed for plasmid DNA delivery . Pluronic F-127 is a triblock copolymer with …Author: Maryam Kouchak
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665163/
The objective of the present study was to design ophthalmic delivery systems based on polymeric carriers that undergo sol-to-gel transition upon change in temperature or in the presence of cations so as to prolong the effect of HP-β-CD Voriconazole (VCZ) in situ gelling formulations.The in situ gelling formulations of Voriconazole were prepared by using pluronic F-127 (PF-127) or with ...Author: Pravin Pawar, Heena Kashyap, Sakshi Malhotra, Rakesh Sindhu
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3007614/
Oct 05, 2010 · To furnish these properties, delivery systems based on the concept of in situ gel formation can be developed. Such delivery systems consist of phase transition systems that are instilled in a liquid form and shift to the gel or solid phase once in the cul-de-sac of the eye.
https://pdfs.semanticscholar.org/e51f/a34c43a4469b888cac3f88f3eb24fcee2d6c.pdf
for the in-situ gel formulations can make them more acceptable and excellent drug delivery systems4. In-Situ Gelling System In-situ forming hydrogels are refer to polymer solution which can be administered as liquid upon instillation and undergo phase transition in the ocular cul-de-sac to form viscoelastic gel and this
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3645361/
Ocular in situ gels are the delivery system, which can be instilled as eye drops and undergo an immediate gelation when in contact with the eye. In situ -forming hydrogels are liquid upon instillation and undergo phase transition in the ocular cul-de-sac to form viscoelastic gel and this provides a response to environmental changes.[ 3 ]
https://www.mdpi.com/2218-0532/78/4/959/pdf
situ gelling system of this drug can provide localized effect with reduced contraindications, improved patient compliance and better therapeutic index. The present work describes the formulation and evaluation of an ophthalmic delivery system of an antiglaucoma drug, timolol maleate (TM) based on the concept of pH-triggered in situ gelation. Polyacrylic acid (carbopol) was used asAuthor: Swati Gupta, Suresh P. Vyas
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