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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865781/
In situ forming polymeric formulations are drug delivery systems that are in sol form before administration in the body, but once administered, undergo gelation in situ, to form a gel.The formation of gels depends on factors like temperature modulation, pH change, presence of ions and ultra violet irradiation, from which the drug gets released in a sustained and controlled manner.
http://ijpsr.com/bft-article/in-situ-gel-sustained-nasal-drug-delivery/?view=fulltext
ABSTRACT: In situ forming polymeric formulations are drug delivery systems that are in sol form before administration in the nasal cavity, but once administered, undergo gelation in situ, to form a gel.The formation of gel depends on factors like temperature modulation, pH change, presence of ions and ultra violet irradiation, from which the drug gets released in a sustained and controlled manner.
https://www.researchgate.net/profile/Zaheer_Abbas33/publication/286292372_Mucoadhesive_in_situ_gels_as_nasal_drug_delivery_systems_An_overview/links/5a962d49a6fdccecff0929c8/Mucoadhesive-in-situ-gels-as-nasal-drug-delivery-systems-An-overview.pdf
In situ forming polymeric formulations are drug delivery systems that are in sol form before administration in the nasal cavity, but once administered, undergo gelation in situ, to form a gel. The ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698857/
Preparation of loratadine in situ nasal gels . A 2 4 factorial design was used for optimization of the process parameters. The composition of different formulations of loratadine in situ nasal gels is shown in Table 1.The drug was dissolved in methanol and 10 ml of distilled water (Milli-Q) was added.
https://www.researchgate.net/publication/323572664_IN-SITU_GEL_FOR_NASAL_DRUG_DELIVERY
In-situ gel for nasal drug deliver y Wu et al . prepared thermo-sensitive in situ nasal gel of insulin using quater nized ch itosan H TCC, P EG and a,b-GP.
https://www.hindawi.com/journals/scientifica/2016/6401267/
The drug has half-life of 4 hrs. Oral bioavailability of timolol maleate is 61%. The aim of the present study was to optimize controlled release in situ nasal delivery for timolol maleate. HPMC and Poloxamer 407 were selected as polymer in formulation of thermoreversible in situ nasal gel.Author: Swati Jagdale, Nirupama Shewale, Bhanudas S. Kuchekar
https://www.sbir.gov/sbirsearch/detail/1574325
In-situ gel of Povidone Iodine/Budesonide as Sustained Nasal Drug Delivery for the Treatment of Chronic Rhinosinusitis ... nasal absorption site and thereby facilitate the uptake of the drugWe propose in this SBIR Phase I to optimize an in situ gel forming nasal spray formulation containing both povidone iodine and budesonide by using ...
http://sphinxsai.com/s_v2_n2/PT_V.2No.2/phamtech_vol2no.2_pdf/PT=67%20(1398-1408).pdf
focused on development of controlled and sustained drug delivery systems. Amongst the extensive research has been carried in designing of polymeric drug delivery systems. The development ofin situ gel systems has received considerable attention over the past few years. In the past few years, increasing number ofin situgel forming systems have been
https://www.sciencedirect.com/science/article/pii/S1359644615003931
Smart materials: in situ gel-forming systems for nasal delivery. ... In this paper we present recent developments on in situ gelling systems for nasal delivery, highlighting the mechanisms that govern their formation. ... Therefore, in situ gel-forming nasal systems show considerable promise in delivery of therapeutics and rapid onset of action.Author: Christina Karavasili, Dimitrios G. Fatouros
https://www.pharmaexcipients.com/wp-content/uploads/attachments/formulation-and-evaluation-of-nasal-in-situ-gel-of-phenylephrine-hydrochloride.pdf?t=1494458446
In situ gel drug delivery systems are in solution form before administration but once administered, undergo gelation in situ, to form a gel. In the present study nasal in situ gel of Phenylephrine hydrochloride was prepared for the treatment of nasal infections to provide sustained release of drug and to attain site specific action.
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