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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109166/
Jun 06, 2011 · Imaging Drug Delivery to Skin with Stimulated Raman Scattering Microscopy. ... Here, stimulated Raman scattering (SRS) microscopy, a recently-developed, label-free chemical imaging tool, is used to acquire high resolution images of multiple chemical components of a topical formulation as it penetrates into mammalian skin. This technique ...Author: Brian G. Saar, L. Rodrigo Contreras-Rojas, X. Sunney Xie, Richard H. Guy
https://pubs.acs.org/doi/abs/10.1021/mp200122w
May 06, 2011 · Efficient drug delivery to the skin is essential for the treatment of major dermatologic diseases, such as eczema, psoriasis and acne. However, many compounds penetrate the skin barrier poorly and require optimized formulations to ensure their bioavailability. Here, stimulated Raman scattering (SRS) microscopy, a recently developed, label-free chemical imaging tool, is used to …Author: Brian G. Saar, L. Rodrigo Contreras-Rojas, X. Sunney Xie, Richard H. Guy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839273/
Apr 21, 2016 · Stimulated Raman scattering microscopy. Coherent Raman scattering microscopy techniques, based on either coherent anti-Stokes Raman scattering (CARS) or stimulated Raman scattering (SRS), have been developed to overcome the low signal levels associated with spontaneous Raman imaging, and hence enhance real-time vibrational imaging of living ...Author: W. J. Tipping, W. J. Tipping, Martin Lee, A. Serrels, V. G. Brunton, A. N. Hulme
https://www.researchgate.net/publication/51104060_Imaging_Drug_Delivery_to_Skin_with_Stimulated_Raman_Scattering_Microscopy
Imaging Drug Delivery to Skin with Stimulated Raman Scattering Microscopy Article in Molecular Pharmaceutics 8(3):969-75 · June 2011 with 158 Reads How we measure 'reads'
http://harvard.sunneyxielab.org/papers/MOL%20PHARM%20v8%20969-75%20JUN%202011%20SAAR.pdf
ABSTRACT: Efficient drug delivery to the skin is essential for the treatment of major dermatologic diseases, such as eczema, psoriasis and acne. However, many compounds penetrate the skin barrier poorly and require optimized formulations to ensure their bioavailability. Here, stimulated Raman scattering (SRS) microscopy, a recently developed,
https://researchportal.bath.ac.uk/en/publications/imaging-drug-delivery-to-skin-with-stimulated-raman-scattering-mi
title = "Imaging drug delivery to skin with stimulated Raman scattering microscopy", abstract = "Efficient drug delivery to the skin is essential for the treatment of major dermatologic diseases, such as eczema, psoriasis and acne.Author: Brian G. Saar, L. Rodrigo Contreras-Rojas, X. Sunney Xie, Richard H. Guy
https://science.sciencemag.org/content/322/5909/1857.full
Dec 19, 2008 · Label-free chemical contrast is highly desirable in biomedical imaging. Spontaneous Raman microscopy provides specific vibrational signatures of chemical bonds, but is often hindered by low sensitivity. Here we report a three-dimensional multiphoton vibrational imaging technique based on stimulated Raman scattering (SRS). The sensitivity of SRS imaging is significantly greater than that of ...Author: Christian W. Freudiger, Wei Min, Brian G. Saar, Sijia Lu, Gary R. Holtom, Chengwei He, Jason C. Tsai...
http://europepmc.org/articles/PMC3109166
May 17, 2011 · Imaging drug delivery to skin with stimulated Raman scattering microscopy. Brian G Saar Department of Chemistry and Chemical Biology, …
https://link.springer.com/chapter/10.1007%2F978-3-642-32109-2_20
Oct 29, 2013 · Coherent Raman scattering microscopy is a new technique allowing high-resolution 3D imaging of the skin, with chemical contrast obtained based on Raman scattering. This technique is label-free and, unlike conventional microscopy techniques, does not rely on fluorescent probes, which are not good models for drug substances because of their ...Author: Natalie A. Belsey, Luis Rodrigo Contreras-Rojas, Richard H. Guy
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