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https://www.sciencedirect.com/science/article/pii/S0887899416302806
The ICV route of administration is an established and globally used method of drug delivery; individual clinics' procedures and recommended guidelines on the use of ICV access devices (e.g., Ommaya and Rickham reservoirs) have been published (summarized in Fig 2).27, 43, 44 Numerous studies have demonstrated that employing strict aseptic ...Author: Jessica L. Cohen-Pfeffer, Sridharan Gururangan, Thomas Lester, Daniel A. Lim, Adam J. Shaywitz, Manf...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042981/
Jan 18, 2011 · Drug injection into the CSF is a slow intravenous infusion. Drug that is injected into the CSF compartment is rapidly transported out of brain to the blood. Following the ICV injection of drug, it moves through the CSF flow tracks, and is absorbed into the peripheral bloodstream across the arachnoid villi to enter the general circulation.Author: William M Pardridge
https://www.sciencedirect.com/science/article/pii/S0169409X20300120
The most common ICV site in humans is the lateral ventricle of the brain. ICV drug administration to the lateral ventricles can be achieved via surgical implantation of a ventricular catheter that is connected to a ventricular access device (also called an Ommaya reservoir).Author: M.J. Fowler, J.D. Cotter, B.E. Knight, E.M. Sevick-Muraca, D.I. Sandberg, D.I. Sandberg, R.W. Sirian...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679837/
May 12, 2013 · The priming allows for the pumps to soak up fluid to initiate the drug delivery as well as come to the proper temperature. Priming time: 14 day pumps: 4-6 hr, 28 day pumps: 40 hr, 42 day pumps: 60 hr. When finished assembling the pumps, cap the conical tubes and place in a clean 37 °C water bath until surgery. ... ICV bolus injections yield a ...Author: Sarah L. DeVos, Timothy M. Miller
https://www.pedneur.com/article/S0887-8994(16)30280-6/pdf
Intrathecal delivery methods have been used for many decades to treat a broad range of central nervous system disorders. A literature review demonstrated that intracerebroventricular route is an established and well-tolerated method for prolonged central nervous system drug delivery in pediatric and adult populations. Intra-
https://www.pedneur.com/article/S0887-8994(16)30280-6/fulltext
The ICV route of administration is an established and globally used method of drug delivery; individual clinics' procedures and recommended guidelines on the use of ICV access devices (e.g., Ommaya and Rickham reservoirs) have been published (summarized in Fig 2).Author: Jessica L. Cohen-Pfeffer, Sridharan Gururangan, Thomas Lester, Daniel A. Lim, Adam J. Shaywitz, Manf...
https://www.jove.com/video/50326/direct-intraventricular-delivery-drugs-to-rodent-central-nervous
Direct Intraventricular Delivery of Drugs to the Rodent Central Nervous System ... be used to deliver ASOs to the CSF. Pumps allow for a slow, continuous delivery, whereas the intracerebroventricular (ICV) bolus is a fast, one-time injection. ... The priming allows for the pumps to soak up fluid to initiate the drug delivery as well as come to ...Author: Sarah L. DeVos, Timothy M. Miller
https://www.researchgate.net/publication/26322515_Intracerebroventricular_Administration_of_Drugs
A recent comprehensive literature review on the clinical use and complications of ICV drug delivery revealed that device-associated complication rates are variable, and may be as high as 33% for ...
https://www.pharmafocusasia.com/articles/blood-brain-barrier-and-cns-drug-delivery
Blood-Brain Barrier and CNS Drug Delivery Parvin Zakeri-Milani , Faculty of Pharmacy, Tabriz University of Medical Sciences, Iran. The central nervous system is protected by barriers which control the passage of various chemical substances and microscopic objects, thereby regulating brain homeostasis.
https://link.springer.com/article/10.1007/s12035-017-0501-y
Apr 28, 2017 · The development of local drug delivery into the CNS was born as response to circumvent the protective features of the BBB. What once was considered to be an obstacle turns out to be an advantage in ICV drug delivery.Author: João Casaca-Carreira, João Casaca-Carreira, Yasin Temel, Yasin Temel, Sarah-Anna Hescham, Sarah-Anna...
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