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https://www.sciencedirect.com/science/article/pii/S0887899416302806
The ICV route of administration is an established and globally used method of drug delivery; individual clinics' procedures and recommended guidelines on the use of ICV access devices (e.g., Ommaya and Rickham reservoirs) have been published (summarized in Fig 2).27, 43, 44 Numerous studies have demonstrated that employing strict aseptic techniques when accessing ICV devices can dramatically ...Author: Jessica L. Cohen-Pfeffer, Sridharan Gururangan, Thomas Lester, Daniel A. Lim, Adam J. Shaywitz, Manf...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227174/
Oct 03, 2011 · Neonatal delivery of AAV9 vectors has been recently utilized to successfully transduce a high percentage of motor neurons using recombinant AAV vectors in SMA mice 7,8. The most important consideration during the ICV injection involves the length of the needle tip. The tip must be long enough such that it can penetrate at least 2 mm in the skull.Author: Jacqueline J. Glascock, Erkan Y. Osman, Tristan H. Coady, Ferrill F. Rose, Monir Shababi, Christian ...
https://www.sciencedirect.com/science/article/pii/S0169409X20300120
Surface properties are also expected to be important following IT nanomedicine delivery. Polyplex charge was observed to mediate periventricular gene delivery via the ICV route . Gene delivery in the spinal cord was observed to be a function of charge density, with a direct, enhancing influence of primary amino groups . Some work has addressed ...Author: M.J. Fowler, J.D. Cotter, B.E. Knight, E.M. Sevick-Muraca, D.I. Sandberg, D.I. Sandberg, R.W. Sirian...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679837/
May 12, 2013 · Both osmotic pumps and a single bolus injection can be used to deliver ASOs to the CSF. Pumps allow for a slow, continuous delivery, whereas the intracerebroventricular (ICV) bolus is a fast, one-time injection.Author: Sarah L. DeVos, Timothy M. Miller
https://en.wikipedia.org/wiki/ICV
Intracerebroventricular (ICV) injection, a medicinal route of administration; This disambiguation page lists articles associated with the title ICV. If an internal link led you here, you may wish to change the link to point directly to the ...
https://www.pedneur.com/article/S0887-8994(16)30280-6/fulltext
Intrathecal delivery methods enable the administration of soluble therapeutics directly into the central nervous system (CNS). As an intrathecal delivery method, the intracerebroventricular (ICV) route of administration instills therapy into the cerebral ventricles via an ICV port implanted under the scalp.Author: Jessica L. Cohen-Pfeffer, Sridharan Gururangan, Thomas Lester, Daniel A. Lim, Adam J. Shaywitz, Manf...
https://www.pedneur.com/article/S0887-8994(16)30280-6/pdf
Intrathecal delivery methods enable the administration of soluble therapeutics directly into the central nervous system (CNS). As an intrathecal delivery method, the intracerebroventricular(ICV)routeofadministrationinstills therapy into the cerebral ventricles via an ICV port implanted under the scalp. This route of administration,
https://www.pnas.org/content/107/9/4424
Mar 02, 2010 · Current solutions for delivery of peptides or secreted proteins to the CNS, for short-term acute administration, include a stereotaxic injection into the ventricular space, known as intracerebroventricular (ICV) administration, or for chronic delivery, an ICV microinjection pump.Author: Limor Regev, Eli Ezrielev, Eran Gershon, Shosh Gil, Alon Chen
https://clinicaltrials.gov/ct2/show/NCT04153175
Nov 06, 2019 · This is a Phase 2 double-blind, randomized, placebo-controlled study to assess the safety and efficacy of ICV delivery of CT-010 via an implantable pump and a cranial port and dual lumen catheter (CIC) in subjects with focal seizures, with temporal lobe …
https://clinicaltrials.gov/ct2/show/NCT02899611
Sep 14, 2016 · In this study, patients with medically refractory focal epilepsy will be treated with intracerebroventricular (ICV) administration of valproate using an implantable drug pump system. This is a dose ranging study, with a randomized, double-blind dose escalation component, to establish the dose range of ICV valproate delivery.
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