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https://www.researchgate.net/publication/8496564_Hydrogel_probe_for_iontophoresis_drug_delivery_to_the_eye
The aim of this study was to evaluate the use of a solid hydrogel loaded with a drug solution as a probe for ejecting drugs to the eye upon application of low current iontophoresis.
https://www.ncbi.nlm.nih.gov/pubmed/15212325
Hydrogel probe for iontophoresis drug delivery to the eye. Eljarrat-Binstock E(1), Raiskup F, Frucht-Pery J, Domb AJ. Author information: (1)Department of Medicinal Chemistry and Natural Products, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel.Author: Esther Eljarrat-Binstock, Frederik Raiskup, Joseph Frucht-Pery, Abraham J. Domb
http://europepmc.org/abstract/MED/15212325
Jan 01, 2004 · Application of iontophoresis onto the rabbit eye caused a reversible swelling of the cornea which lasted a few hours after application. Low current iontophoresis using drug-loaded hydrogel has a potential clinical value in obtaining high drug concentration at posterior segments of the eye.Author: Esther Eljarrat-Binstock, Frederik Raiskup, Joseph Frucht-Pery, Abraham J. Domb
https://www.sciencedirect.com/science/article/pii/S0168365905005286
Iontophoresis as a non-invasive technique for ocular drug delivery has been investigated for many years. This paper provides an overview of the approaches currently used in the development of the ocular iontophoretic device, the essential features of this procedure and the reported toxicity.Author: Esther Eljarrat-Binstock, Abraham J. Domb
https://www.sciencedirect.com/science/article/pii/S001448350300215X
In the present study, we established the efficacy of the iontophoresis–hydrogel-probe drug delivery system in an animal model. Iontophoresis with the novel hydrogel probe permits delivery of therapeutic gentamicin concentrations into the rabbit cornea ( Table 1 ) that was comparable to gentamicin applied topically or injected sub-conjunctivally.Author: Joseph Frucht-Pery, Hadas Mechoulam, Charalambos S Siganos, Pnina Ever-Hadani, Mervyn Shapiro, Abrah...
https://www.researchgate.net/publication/5649356_Charged_nanoparticles_delivery_to_the_eye_using_hydrogel_iontophoresis
Charged nanoparticles delivery to the eye using hydrogel iontophoresis Article (PDF Available) in Journal of Controlled Release 126(2):156-61 · April 2008 with 77 Reads How we measure 'reads'
https://www.ncbi.nlm.nih.gov/pubmed/16758757
The aim of this study was to evaluate the use of solid hydrogel as a probe for the drug delivery to the rabbit eye upon application of low current iontophoresis. Hydroxyethyl methacrylate (HEMA), cross-linked with ethylenglycol dimethacrylate (EGDMA) were prepared to form solid hydrogels.Author: Raiskup-Wolf F, Eljarrat-Binstock E, Rehák M, Domb A, Frucht-Pery J
http://retinatoday.com/2011/03/ocular-iontophoresis-for-drug-delivery
The first transscleral iontophoretic application for vitreal drug delivery was reported in 1943. 4 Later, David Maurice played a pivotal role in advancing the use of iontophoresis to enhance ocular drug delivery, 5,6 but techniques for ophthalmic iontophoresis have taken decades to evolve. Although scientists, engineers, and ophthalmologists ...
https://fohs.bgu.ac.il/homes/stepensky/mypapers/15.%202004%20iontophoresis_iovs.pdf
Delivery of Gentamicin to the Rabbit Eye by Drug-Loaded Hydrogel Iontophoresis Esther Eljarrat-Binstock, 1Frederik Raiskup,2 David Stepensky,3 Abraham J. Domb, and Joseph Frucht-Pery2 PURPOSE. To assess the corneal iontophoretic delivery of gen-tamicin by drug-loaded hydrogel probe, and to determine the
https://link.springer.com/chapter/10.1007/978-3-319-95807-1_14
Oct 09, 2018 · Abstract. Drug delivery to the eye still is a challenge due to its intricate anatomical structure. Posterior segment delivery is much more challenging due to the acellular nature of the vitreous humor and the longer diffusion distance to the retina.Author: Dherya Bahl, Rinda Devi Bachu, Mrudula Chitti, Pallabita Chowdhury, Jwala Renukuntla, Sai H. S. Bodd...
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