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https://www.ncbi.nlm.nih.gov/pubmed/2568439
Hydrogel patches based on water swellable polyacrylates have been developed for long-term transdermal drug delivery. Two properties, relevant to the performance of hydrogel patches in-vivo have been investigated in humans over five days.Author: H. E. Boddé, E. A. C. Van Aalten, H. E. Junginger
https://www.sciencedirect.com/science/article/pii/S0378517313006017
The effect of different preparation parameters were analyzed with respect to the rheological and pharmaceutical characteristics of hydrogel blend patches, as transdermal delivery formulation. Mixtures of pectin and gelatin were employed for the production of patches, with adjustable properties, following a two-step gelation procedure.Author: Stefania Mazzitelli, Cinzia Pagano, Danilo Giusepponi, Claudio Nastruzzi, Luana Perioli
https://www.sciencedirect.com/science/article/pii/S0168365920301784
Novel drug delivery methods are needed to reduce dosing frequency. • Microneedle technology has proven benefits as a method of minimally invasive drug delivery. • Hydrogel-forming microneedles enhance transdermal delivery of esketamine in vivo. • Therapeutic plasma levels of >0.15–0.3 μg/ml were achieved in rats over 24 h.Author: Aaron J. Courtenay, Aaron J. Courtenay, Emma McAlister, Maelíosa T.C. McCrudden, Lalit Vora, Lilach ...
https://www.drugdiscoverytrends.com/alliqua-ceo-hydrogel-based-transdermal-drug-delivery-an-innovative-alternative/
Sep 19, 2013 · For thousands of years, people have placed substances on the skin for therapeutic effects, and, in the modern era, a variety of topical formulations have been developed to treat local indications. Transdermal drug delivery (TDD) represents an attractive alternative to other drug delivery methods and an increasingly promising player in the $142 billion drug delivery…
http://onlinelibrary.wiley.com/doi/10.1111/j.2042-7158.1989.tb06419.x/abstract
Apr 12, 2011 · Abstract. Abstract— Hydrogel patches based on water swellable polyacrylates have been developed for long-term transdermal drug delivery. Two properties, relevant to the performance of hydrogel patches in-vivo have been investigated in humans over five days. These were: (i) the kinetics of water exchange between the skin and the patches; (ii) the skin compatibility of the patches.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882498/
Nov 18, 2019 · Nanoemulgels are composed of O/W nanoemulsion and hydrogels and are considered as ideal carriers for the transdermal drug delivery because these have high affinity to load hydrophobic drugs. The stable formulation of eprinomectin (EPR) is very challenging because of it …Author: Yujuan Mao, Xiaolan Chen, Bohui Xu, Yan Shen, Zixuan Ye, Birendra Chaurasiya, Li Liu, Yi Li, Xiaolin...
https://link.springer.com/article/10.1007%2FBF03353783
Jul 01, 2014 · This article will focus on the microneedle arrays consisting of hydrogels. Hydrogels are commonly used in drug delivery field. Hydrogel microneedles can be further divided into dissolving and degradable microneedles and phase transition microneedles. The …Author: Xiaoyun Hong, Zaozhan Wu, Lizhu Chen, Fei Wu, Liangming Wei, Weien Yuan
https://onlinelibrary.wiley.com/doi/full/10.1002/adfm.201200864
(d) uses hollow MN for delivery of fluids containing drug. e–h) Our novel hydrogel‐forming polymeric MN for controlled transdermal drug delivery. (e) shows an exploded view of our novel integrated hydrogel MN patch, which consists of a backing layer, a drug‐loaded adhesive patch and a …Author: Ryan F. Donnelly, Thakur Raghu Raj Singh, Martin J. Garland, Katarzyna Migalska, Rita Majithiya, Cia...
https://www.nature.com/articles/s41598-020-58822-w
Feb 06, 2020 · Ultrasonically and Iontophoretically Enhanced Drug-Delivery System Based on Dissolving Microneedle Patches. ... in transdermal drug delivery, ... from the hydrogel to stop drug release. ...Author: Moonjeong Bok, Zhi-Jun Zhao, Sohee Jeon, Jun-Ho Jeong, Eunju Lim
https://www.researchgate.net/publication/321228273_HYDROGELS_IN_TOPICAL_DRUG_DELIVERY_-_A_REVIEW
This review disclose the convenience of hydrogel as a topical drug delivery system anywhere in the body by the route of ophthalmic, rectal, vaginal and skin. ... Topical patches do not possess the ...
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