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https://www.sciencedirect.com/science/article/pii/S0168365912007596
Another pH-responsive hydrogel device comprising of psyllium and acrylamide/methacrylamide based hydrogels using N,N′-methylenebisacrylamide (N,N′-MBAAm) was studied for oral insulin delivery. This system exhibited dual potential of sustained and controlled release of insulin together with the generation of psyllium after degradation that showed additional glucose lowering effect.Author: Kiran Chaturvedi, Kuntal Ganguly, Mallikarjuna N. Nadagouda, Tejraj M. Aminabhavi
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986559/
A trehalose-boronic acid hydrogel is synthesized for glucose-responsive insulin delivery and stabilization. A trehalose glycopolymer is cross-linked with boronic acid end-functionalized PEG to encapsulate insulin.Author: Juneyoung Lee, Jeong Hoon Ko, Kathryn M. Mansfield, Peter C. Nauka, Erhan Bat, Erhan Bat, Heather D....
https://www.sciencedirect.com/science/article/pii/S1742706117300168
The glucose-sensitive insulin delivery system consists of pH-sensitive peptide hydrogel, encapsulated insulin and enzymes that can convert glucose into gluconic acid and then change the local pH. When the pH level is below the pKa of the lysine/ornithine side chains; there would be electrostatic repulsion between them and subsequent unfolding of individual hairpins.Author: Xue Li, Mian Fu, Jun Wu, Chenyu Zhang, Xin Deng, Arvind Dhinakar, Wenlong Huang, Hai Qian, Liang Ge
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079503/
The recovery percentages of insulin with the original insulin activity after 2 months storage proved good stability of the pectin insulin hydrogel insulin matrix patch. The stability of insulin in formulations is an important issue since aggregation of insulin is known to lead to severely reduced biological activity [52] .Author: Silindile I. Hadebe, Phikelelani S. Ngubane, Metse R. Serumula, Cephas T. Musabayane
https://pubs.acs.org/doi/abs/10.1021/acs.molpharmaceut.6b00875
Here a series of new Salecan-based pH-sensitive hydrogels were fabricated for controlled insulin delivery via the graft copolymerization reaction between Salecan and 2-acrylamido-2-methyl-1-propanesulfonic acid. In this study, on one hand, Salecan played a key role in modifying the structure and the pore size of the developing hydrogel.Author: Xiaoliang Qi, Wei Wei, Junjian Li, Gancheng Zuo, Xihao Pan, Ting Su, Jianfa Zhang, Wei Dong
https://www.sciencedirect.com/science/article/pii/S0032386110001321
The oral drug delivery of insulin by various means is a challenge because it is a protein in nature and can be digested in the stomach and the gut. Generally, diabetic patients prefer oral intake in the form of pill having mostly hypoglycemic agents to avoid injection of insulin. In this regard, carrageenan based hydrogel is developed for insulin delivery.Author: Nadia Rasool, Nadia Rasool, Nadia Rasool, Tariq Yasin, Jerry Y.Y. Heng, Zareen Akhter
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793577/
Numerous studies have assessed the feasibility of various PECs for the delivery of insulin including alginate–chitosan [7,8], chitosan–poly(γ-glutamic acid) , and chitosan–arabic gum systems . The benefit of these hydrogel systems is that the drug can be encapsulated easily by creating a water-based ionotropic gel, which protects the bioactive structure of insulin [ 11 ].Author: Mokhamad Nur, Todor Vasiljevic
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