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https://www.sciencedirect.com/science/article/pii/S0032386108000487
Hydrogels used in drug delivery are usually formed outside of the body and impregnated with drugs before placement of the hydrogel–drug complex in the body. A wide range of cross-linking strategies can be used, including UV photopolymerization and various chemical cross-linking techniques.Author: Todd R. Hoare, Daniel S. Kohane
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898614/
Hydrogel delivery systems can leverage therapeutically beneficial outcomes of drug delivery and have found clinical use. Hydrogels can provide spatial and temporal control over the release of various therapeutic agents, including small-molecule drugs, macromolecular drugs and cells.Author: Jianyu Li, David J. Mooney
https://www.nature.com/articles/natrevmats201671
Oct 18, 2016 · Hydrogel delivery systems can leverage therapeutically beneficial outcomes of drug delivery and have found clinical use. Hydrogels can provide spatial and temporal control over the release of various therapeutic agents, including small-molecule drugs, macromolecular drugs and cells.Author: Jianyu Li, David J. Mooney
https://www.sciencedirect.com/science/article/pii/S1359029497801033
Hydrogels and drug delivery Nikolaos A Peppas Recent developments include the use of water-swollen, crosslinked biomedical polymers as carriers for the delivery of drugs, peptides and proteins, as targeting agents for site-specific delivery, or as components for preparation of protein or enzyme conjugates.Author: Nikolaos A Peppas
https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.9b01020
As an emerging drug carrier, hydrogels have been widely used for tumor drug delivery. A hydrogel drug carrier can cause less severe side effects than systemic chemotherapy and can achieve sustained delivery of a drug at tumor sites.Author: Zhaoyi Sun, Chengjun Song, Chao Wang, Yiqiao Hu, Jinhui Wu
https://www.sciencedirect.com/science/article/pii/S0168365920302108
Apr 02, 2020 · Nanoparticles (NPs), polyspheres and copolymer hydrogels have for instance found a wide range of application as controlled drug delivery system in biomedical research [,,,, ], including also cancer research and photothermal therapy [ 19 ].
https://pubs.rsc.org/en/content/articlelanding/2020/tb/c9tb01610d
The well-developed gene delivery system provided a potential treatment with high specificity and selectivity toward TNBCs. This strategy can be implemented in triplex-helix hydrogel design to form novel miRNA combinations to treat various human cancers.Author: Lairong Ding, Lairong Ding, Junwei Li, Junwei Li, Changrong Wu, Feng Yan, Xuemei Li, Shusheng Zhang
http://www.orientjchem.org/vol29no3/hydrogels-smart-materials-for-drug-delivery/
Emergence of hydrogels as drug delivery system The word smart polymers originated from the ability of hydrogels to imitate the non-linear response of DNA and Proteins. 11 Above all the characteristic features of hydrogels, their behaviour to adapt structural changes in response to various physical or chemical trigger (Figure 3) and make them intelligent candidates for drug delivery system. The current drug delivery …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549393/
Intestinal drug delivery systems take advantage of pH-responsive anionic hydrogels to protect drugs from gastric degradation and denaturation at low pH and release drugs in specific locations, such as the upper small intestine and colon, further in the GI tract.Author: Lindsey A Sharpe, Adam M Daily, Sarena D Horava, Nicholas A Peppas
http://isn.ucsd.edu/courses/beng221/problems/2012/BENG221_Project%20-%20Wei%20Kim%20Kim%20Limsakul.pdf
delivery system comprises a drug core entrapped in a spherical, cylindrical, and slab-like-shaped reservoir, which is in turn encapsulated within a hydrogel membrane. In order to ensure drug delivery at a constant rate, the drug can be concentrated in the center of the device such that the
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