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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064722/
Hydrodynamic delivery is one of non-viral methods developed originally for intracellular gene delivery but later found applicable to delivery of other macromolecules such as oligo nucleotides, RNA, proteins, and the compounds that are not permeable to cell membrane.Author: Barbara Bonamassa, Li Hai, Dexi Liu
https://www.sciencedirect.com/science/article/pii/S0065266005540045
Hydrodynamic delivery employs the force generated by the rapid injection of a large volume of solution into the incompressible blood in the circulation to overcome the physical barriers of endothelium and cell membranes that prevent large and membrane‐impermeable compounds from entering parenchymal cells.
https://www.sciencedirect.com/science/article/pii/S0065266014000030
Hydrodynamic delivery (HD) is a broadly used procedure for DNA and RNA delivery in rodents, serving as a powerful tool for gene/protein drug discovery, gene function analysis, target validation, and identification of elements in regulating gene expression in vivo. HD involves a pressurized injection of a large volume of solution into a vasculature.
https://www.sciencedirect.com/science/article/pii/S1525001616327198
Hydrodynamic gene delivery has been shown to be able to promote both humoral- and cell-based immunity in animals in a gene dependent manner. Hydrodynamic gene delivery generates much more gene product than does the commonly used method of intramuscle injection of plasmid DNA.Author: Takeshi Suda, Dexi Liu
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4412368/
Hydrodynamic delivery to the hepatocytes is a nonspecific process To evaluate the versatility of the hydrodynamics-based procedure at the cellular level and to determine the mechanistic nature of the intracellular delivery, we have injected into mice with various types of molecules that are different in structure and property.Author: G Zhang, X Gao, YK Song, R Vollmer, DB Stolz, JZ Gasiorowski, DA Dean, D Liu
https://www.researchgate.net/publication/271535808_Hydrodynamic_Delivery
Hydrodynamic delivery (HD) is a broadly used procedure for DNA and RNA delivery in rodents, serving as a powerful tool for gene/protein drug discovery, gene function analysis, target validation,...
https://www.researchgate.net/publication/7664463_Hydrodynamic_Delivery
Hydrodynamic delivery employs the force generated by the rapid injection of a large volume of solution into the incompressible blood in the circulation to overcome the physical barriers of...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218527/
Oct 15, 2011 · The hydrodynamic delivery method is a method developed for delivery of either DNA or siRNA for gene function and gene therapy studies in rodents. 8 – 11 It involves a rapid tail-vein injection of a large volume (equal to 8–10% body weight) of siRNA/DNA solution into a mouse or rat to build high intravascular pressure, consequently, increasing endothelia permeability and facilitating intracellular …Author: Jianfeng Li, Qian Yao, Dexi Liu
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198622/
However, under experimental conditions utilizing the hydrodynamic delivery of 10% of body weight, one must take into account the possibility of sustained and severe liver damage, which might alter gene expression and induce inflammatory cytokine production, whereas on injecting lower volumes, tissue damage appears to be transient with a low ...Author: Zsuzsanna Rácz, Mária Godó, Csaba Révész, Péter Hamar
https://www.sciencedirect.com/science/article/pii/S0006295220301313
Hydrodynamic delivery of pcDNA 3-CCL4 evoked a time-dependent biphasic effect on thermal nociception mediated through CCR5 receptors. Thermal nociceptive latencies were assessed at different times after the administration of 1 mg/kg of pcDNA 3-CCL4 plasmid.Author: Alina Aguirre, Sara González-Rodríguez, Mario García-Domínguez, Ana Lastra, Ana Gutiérrez-Fernández,...
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