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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182354/
Jul 12, 2011 · Random integration of conventional gene delivery vectors such as viruses, plasmids, P1 phage-derived artificial chromosomes, bacterial artificial chromosomes and yeast artificial chromosomes can be associated with transgene silencing. Furthermore, integrated viral sequences can activate oncogenes adjacent to the insertion site resulting in cancer.Author: Yasuhiro Kazuki, Mitsuo Oshimura
https://www.cell.com/molecular-therapy-family/molecular-therapy/pdf/S1525-0016(16)32744-7.pdf
of gene delivery because such viruses can transduce dividing and quiescent cells.9–12 HIV-based vectors have recently been utilized successfully for human gene correction, although integrations of the vectors into the host genome were observed.13,14 Recently, integration-deficient lentiviral vectors were developed through
https://www.nature.com/articles/gt2009102
Aug 27, 2009 · Artificial chromosomes (ACs) are highly promising vectors for use in gene therapy applications. They are able to maintain expression of genomic-sized exogenous transgenes within target cells ...Author: S Macnab, A Whitehouse
https://musculardystrophynews.com/2018/02/05/researchers-use-artificial-chromosomes-to-deliver-gene-therapy-for-duchenne-md/
Scientists have developed a replacement gene delivery mechanism called human artificial chromosomes that can carry bigger genes like dystrophin. In a previous study, a group of researchers used stem-cell-like mesoangioblasts to generate the dystrophin protein that was missing in …
https://www.sciencedirect.com/science/article/pii/S1525001616327447
An example for the construction of engineered human artificial chromosomes (HACs) via top-down approach and subsequent gene delivery. (a) HAC construction. 21HAC1 is generated by insertion of a loxP site into a pericentromeric region of the q-arm of an hChr. 21 and subsequent truncation of the p- …Author: Yasuhiro Kazuki, Mitsuo Oshimura
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522797/
Since their description in the late 1990s, human artificial chromosomes (HACs) carrying a functional kinetochore were considered as a promising system for gene delivery and expression with a potential to overcome many problems caused by the use of viral-based gene transfer systems.Author: Natalay Kouprina, William C. Earnshaw, Hiroshi Masumoto, Vladimir Larionov
https://academic.oup.com/dnaresearch/article/17/5/293/353856
Human artificial chromosomes (HACs) are an important alternative to conventional gene-transfer techniques, such as viral, plasmid, P1 phage-derived artificial chromosomes, bacterial artificial chromosomes (BACs) and yeast artificial chromosomes, because they offer greater control over their location and function in recipient human cells.Author: Yuichi Iida, Jung-Hyun Kim, Yasuhiro Kazuki, Hidetoshi Hoshiya, Masato Takiguchi, Masahiro Hayashi, ...
https://www.nature.com/articles/gt2010147
Nov 18, 2010 · Human artificial chromosomes (HACs) have several advantages as gene therapy vectors, including stable episomal maintenance, and the ability to carry large gene inserts. ...Author: Y Kazuki, H Hoshiya, M Takiguchi, S Abe, Y Iida, M Osaki, M Katoh, M Hiratsuka, Y Shirayoshi, K Hira...
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