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https://www.hcs.harvard.edu/~jus/england.pdf
mediately suits it to protein drug Stabilization and Release Effects of Pluronic F127 in Protein Drug Delivery Jeremy L. England This paper explores the biochemistry of the surfactant hydrogel Pluronic F127 in its capacity as a protein drug delivery mechanism. Computer modeling techniques were used to simulate the behavior
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019320/
Here, we developed Pluronic[®] P123/F127 (poloxamer) mixed micelles for the intravenous delivery of the anticancer drug sorafenib (SRB) or its combination with verteporfin (VP), a photosensitizer for photodynamic therapy that should complement ...Author: Diogo Silva Pellosi, Francesca Moret, Aurore Fraix, Nino Marino, Sara Maiolino, Elisa Gaio, Noboru H...
https://www.sciencedirect.com/science/article/pii/S037851731630120X
This study evaluated the use of Pluronic F127 and Pluronic F68 as excipients for formulating in situ gelling systems for ocular drug delivery. Thermal transitions have been studied in aqueous solutions of Pluronic F127, Pluronic F68 as well as their binary mixtures using differential scanning calorimetry, rheological measurements, and dynamic light scattering.Author: Kosai Al Khateb, Elvira K. Ozhmukhametova, Marat N. Mussin, Serzhan K. Seilkhanov, Tolebai K. Rakhyp...
https://www.sciencedirect.com/science/article/pii/S0021979719315632
Pluronic F127 thermosensitive injectable smart hydrogels for controlled drug delivery system development. Author links open overlay panel Bana Shriky a Adrian Kelly a Mohammad Isreb b Maksims Babenko a Najet Mahmoudi c Sarah Rogers c Olga Shebanova d Tim Snow d Tim Gough a. Show more.Author: Bana Shriky, Adrian Kelly, Mohammad Isreb, Maksims Babenko, Najet Mahmoudi, Sarah Rogers, Olga Sheba...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075891/
Jan 19, 2011 · This has significant positive implications for the toxicity and economic issues related to using F127 in drug delivery. Adjusting the amount of liposome in gels is an easy, flexible means of adjusting the drug dose required to meet different therapeutic needs of individual patients. Secondly, in vitro cytotoxicity and drug uptake in KB cancer ...Author: Shufang Nie, WL Wendy Hsiao, Weisan Pan, Zhijun Yang
https://pubs.acs.org/doi/abs/10.1021/la304836e
Three drugs, ibuprofen, aspirin, and erythromycin, are encapsulated in spherical Pluronic F127 micelles. The shapes and the size distributions of the micelles in dilute, aqueous solutions, with and without drugs, are ascertained using cryo-scanning electron microscopy and dynamic light scattering (DLS) experiments, respectively. Uptake of drugs above a threshold concentration is seen to reduce ...Author: Rajib Basak, Ranjini Bandyopadhyay
https://www.mdpi.com/2079-4983/9/1/11/pdf
F127 12,600 65 200 0.7 0.1 0.025 ... drug delivery for surface modification, the stabilization of colloids and as an excipient to form solid particles [50]. The microphase separation that results in thermodynamically-stable micelles involves two processes [51]. The first process is fast (hundredths-to-tenths of milliseconds) and representsAuthor: Andrew M. Bodratti, Paschalis Alexandridis
https://bmcbiotechnol.biomedcentral.com/articles/10.1186/1472-6750-9-8
Feb 11, 2009 · Most conventional methods for delivering chemotherapeutic agents fail to achieve therapeutic concentrations of drugs, despite reaching toxic systemic levels. Novel controlled drug delivery systems are designed to deliver drugs at predetermined rates for predefined periods at the target organ and overcome the shortcomings of conventional drug formulations therefore could diminish the side ...Author: Chang Yang Gong, Shuai Shi, Peng Wei Dong, Xiu Ling Zheng, Shao Zhi Fu, Gang Guo, Jing Liang Yang, Y...
https://www.researchgate.net/publication/267744212_Pluronics_F-127L-81_Binary_Hydrogels_as_Drug-Delivery_Systems_Influence_of_Physicochemical_Aspects_on_Release_Kinetics_and_Cytotoxicity
Pluronics F-127/L-81 Binary Hydrogels as Drug-Delivery Systems: Influence of Physicochemical Aspects on Release Kinetics and Cytotoxicity ... Pluronic-F127 (PF-127), has been chosen to prepare the ...
https://www.nature.com/articles/s41598-017-03123-y
Jun 07, 2017 · A novel polymeric mixed micelle composed of Pluronic F127 and D-α-tocopheryl polyethylene glycol succinate (TPGS) was developed to improve the delivery of fluorescent dyes and protein across the ...Author: Xin Meng, Jiansheng Liu, Xiangrong Yu, Jiajia Li, Xiaotong Lu, Teng Shen
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