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https://www.ncbi.nlm.nih.gov/pubmed/21517984
A clinician must weigh the risks and benefits of possible over-dosing or under-dosing based on the therapeutic index of the drug and the clinical situation. This article will review the important factors to consider for drug dosing in patients with AKI receiving continuous renal replacement therapy and sustained low-efficiency dialysis.Author: Linda Awdishu, Josée Bouchard
https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1525-139X.2011.00826.x
Patients with AKI are therefore at risk for adverse outcomes of drug therapy. It has been reported that approximately half of patients with reduced renal clearance receive drug doses that are 2.5 times higher than the recommended maximum dose. To ensure efficacy and prevent toxicity, therapeutic drug monitoring is highly recommended.Author: Linda Awdishu, Josée Bouchard
https://www.researchgate.net/publication/51074969_How_to_Optimize_Drug_Delivery_in_Renal_Replacement_Therapy
The use of renal replacement therapy for DIKD is twofold, firstly, dialysis can be utilized to remove the offending drug and minimize ongoing damage; additionally, dialysis can be utilized to ...
https://www.academia.edu/28380442/How_to_Optimize_Drug_Delivery_in_Renal_Replacement_Therapy
How to Optimize Drug Delivery in Renal Replacement Therapy
http://www.uphs.upenn.edu/surgery/Education/trauma/SCC/CPGs/CRRT_Antimicrobial_Dosing_Table.pdf
delay antibiotic therapy pending clinical specialist dose verification. There are many factors to consider which affect drug clearance on CVVHD, which may lead to a dosing recommendation that differs from what is outlined below. These factors include: Drug and Dialysate Factors Dialysate Factors Patient Characteristics . Drug molecular weightFile Size: 161KB
http://onlinelibrary.wiley.com/doi/10.1111/j.1525-139X.2011.00831.x/abstract
Apr 25, 2011 · 14 Wilfred Druml, Nutritional Management of Renal Disease, 2013, 605CrossRef; 15 Enrico Fiaccadori, Giuseppe Regolisti, Umberto Maggiore, Specialized nutritional support interventions in critically ill patients on renal replacement therapy, Current Opinion in Clinical Nutrition and Metabolic Care, 2013, 16, 2, 217CrossRef
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