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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048892/
Gold nanoparticles provide an attractive and applicable scaffold for delivery of nucleic acids. In this review, we focus on the use of covalent and noncovalent gold nanoparticle conjugates for applications in gene delivery and RNA-interference technologies.Author: Ya Ding, Ya Ding, Ziwen Jiang, Krishnendu Saha, Chang Soo Kim, Sung Tae Kim, Ryan F Landis, Vincent ...
https://www.sciencedirect.com/science/article/pii/S1525001616306967
Gold nanoparticles provide an attractive and applicable scaffold for delivery of nucleic acids. In this review, we focus on the use of covalent and noncovalent gold nanoparticle conjugates for applications in gene delivery and RNA-interference technologies.Author: Ya Ding, Ya Ding, Ziwen Jiang, Krishnendu Saha, Chang Soo Kim, Sung Tae Kim, Ryan F Landis, Vincent ...
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(16)30696-7
Jun 01, 2014 · Gold nanoparticles provide an attractive and applicable scaffold for delivery of nucleic acids. In this review, we focus on the use of covalent and noncovalent gold nanoparticle conjugates for applications in gene delivery and RNA-interference technologies. We also discuss challenges in nucleic acid delivery, including endosomal entrapment/escape and active delivery/presentation of nucleic ...Author: Ya Ding, Ya Ding, Ziwen Jiang, Krishnendu Saha, Chang Soo Kim, Sung Tae Kim, Ryan F Landis, Vincent ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982881/
Jan 03, 2020 · In such 3D configuration the presence of gold nanoparticles and PEG enhances gene delivery potential and lowers cytotoxic effect, compared to the dendrimer alone. The nanodevice was further conjugated with nucleic acid and effectively silenced the gene expression.Author: Anna Graczyk, Roza Pawlowska, Dominika Jedrzejczyk, Arkadiusz Chworos
https://www.researchgate.net/publication/260557099_Gold_Nanoparticles_for_Nucleic_Acid_Delivery
Gold nanoparticles provide an attractive and applicable scaffold for delivery of nucleic acids. In this review, we focus on the use of covalent and noncovalent gold nanoparticle conjugates for ...
https://www.cell.com/molecular-therapy-family/molecular-therapy/pdf/S1525-0016(16)30696-7.pdf
Gold nanoparticles provide an attractive and applicable scaffold for delivery of nucleic acids. In this review, we focus on the use of covalent and noncovalent gold nanoparticle conjugates for applications in gene deliv-ery and RNA-interference technologies. We …
https://www.sciencedirect.com/science/article/pii/B978008100557600002X
2.4. Nanoparticles as nonviral nucleic acid delivery vectors. Nucleic acid as a therapeutic agent is an important tool to treat the more serious diseases which require systemic administration of the gene or nucleic acid substances to enter the target cells (Luten et al., 2008). Today, effective gene delivery to the target tissue has become a ...Author: Ashok Kumar Sharma, Lokesh Gupta, Umesh Gupta
https://pubs.acs.org/doi/10.1021/nl1041947
We report a gold nanoparticle-templated high density lipoprotein (HDL AuNP) platform for gene therapy that combines lipid-based nucleic acid transfection strategies with HDL biomimicry. For proof-of-concept, HDL AuNPs are shown to adsorb antisense cholesterylated DNA. The conjugates are internalized by human cells, can be tracked within cells using transmission electron microscopy, and ...Author: Kaylin M. McMahon, R. Kannan Mutharasan, Sushant Tripathy, Dorina Veliceasa, Mariana Bobeica, Dale K...
https://pubs.acs.org/doi/10.1021/ja908117a
Over the past decade, gold nanoparticles have been developed that demonstrate a wide variety of applications, including catalysis, bioanalysis, and imaging. Gold nanoparticles are also an ideal drug-delivery scaffold because they are known to be nontoxic and nonimmunogenic.Author: Sarah D. Brown, Paola Nativo, Jo-Ann Smith, David Stirling, Paul R. Edwards, Balaji Venugopal, David...
https://pubs.rsc.org/en/content/articlelanding/2015/ra/c4ra16294c#!
Positively charged, surfactant–free gold nanoparticles (Au NPs) with diameters ranging between 2–200 nm have been synthesised in water via a seed-mediated growth method, involving the reduction of gold(iii) chloride (AuCl3) by hydroxylamine hydrochloride (NH2OH·HCl) in the presence of l …
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