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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947805/
Organelle-specific delivery or delivery of the drug or drug-loaded nanocarriers directly to the site of drug action is required to achieve maximum therapeutic with a minimum of off-target effects. 5.1.Author: Swati Biswas, Swati Biswas, Vladimir P. Torchilin
https://www.onlinelibrary.wiley.com/doi/book/10.1002/9780470875780
Aug 25, 2010 · He has coauthored more than twenty peer-reviewed publications in the fields of pharmaceutical nanotechnology and mitochondrial pharmaceutics. Dr. D'Souza is a member of the editorial board for the Journal Drug Delivery and serves as a peer reviewer for several journals in the field of drug delivery.
https://www.dovepress.com/organelle-targeting-third-level-of-drug-targeting-peer-reviewed-article-DDDT
Organelle targeting: third level of drug targeting Niraj M Sakhrani, Harish PadhDepartment of Cell and Molecular Biology, BV Patel Pharmaceutical Education and Research Development (PERD) Centre, Gujarat, IndiaAbstract: Drug discovery and drug delivery are two main aspects for treatment of a variety of disorders. However, the real bottleneck associated with systemic drug administration is the ...
https://www.springer.com/gp/book/9783319113548
This authoritative volume explores the fundamental concepts and numerous applications of targeted delivery of drugs to the body. This compilation has been divided into eight sections comprised of the basic principles of drug targeting, disease and organ/organelle-based targeting, passive and active
https://www.pnas.org/content/pnas/117/6/2770.full.pdf
nonviral delivery systems (vectors), which are highly sought-after based on their tunable payload capacities, reduced pathogenicity, and low immunogenicity (14). Nevertheless, it remains challenging to engineer organelle-specific, nuclear-targeting nanoparticles that shuttle therapeutic payloads directly into the nucleus (15). Key
https://www.pnas.org/content/117/6/2770
Organelle-specific targeting of polymersome NCs into the cell nucleus. (A) NLS-NCs self-assemble from amphiphilic PMOXA-PDMS-PMOXA triblock copolymers. Two model compounds are used to test for nuclear delivery: Ruthenium Red (RR) that is encapsulated within the NLS-NC lumen, and Bodipy 630/650 that incorporates into its polymeric membrane.
https://www.tandfonline.com/doi/abs/10.1080/17425247.2018.1547280
ABSTRACTIntroduction: Pulmonary drug delivery is organ-specific and benefits local drug action for lung cancer. The use of nanotechnology and targeting ligand enables cellular-specific drug action. Combination approaches increase therapeutic efficacy and reduce adverse effects of cancer chemotherapeutics that have narrow therapeutic index window and high cytotoxicity levels.
https://www.sciencedirect.com/science/article/abs/pii/S0169409X07000932
This review is part of the Advanced Drug Delivery Reviews theme issue on “Organelle-Specific Targeting in Drug Delivery and Design".
https://link.springer.com/chapter/10.1007/978-981-13-3642-3_12
Himri I, Guaadaoui A (2018) Chapter 1 – cell and organ drug targeting: types of drug delivery systems and advanced targeting strategies. In: Grumezescu AM (ed) Nanostructures for the engineering of cells, tissues and organs. William Andrew Publishing, Oxford, pp 1–66 Google Scholar
https://www.nibib.nih.gov/science-education/science-topics/drug-delivery-systems-getting-drugs-their-targets-controlled-manner
Drug delivery systems are engineered technologies for the targeted delivery and/or controlled release of therapeutic agents. Drugs have long been used to improve health and extend lives. The practice of drug delivery has changed dramatically in the past few decades and even greater changes are anticipated in the near future.
https://pubs.acs.org/doi/abs/10.1021/acs.bioconjchem.9b00456
Aug 23, 2019 · This Topical Review will first discuss the evolution and progress of nanoparticles for cancer drug delivery and the current challenges that remain to be addressed. Strategies for overcoming the limitations of passive targeting through active targeting approaches, and the current state of such nanomedicines in the clinic will be highlighted.
https://biomaterialsres.biomedcentral.com/articles/10.1186/s40824-018-0145-7
Interest in subcellular organelle-targeting theranostics is substantially increasing due to the significance of subcellular organelle-targeting drug delivery for maximizing therapeutic effects and minimizing side effects, as well as the significance of theranostics for delivering therapeutics at the correct locations and doses for diseases throughout diagnosis. Among organelles, mitochondria ...
https://www.hindawi.com/journals/jnm/2016/1087250/
In this paper, we provide an overview of three different targeted drug delivery methods (passive targeting, active targeting, and physical targeting) and compare methods of action, advantages, limitations, and the current stages of research. For the most commonly used nanoparticle carriers, fabrication methods are also reviewed.
https://www.mdpi.com/1999-4923/11/8/407
Notable attention is given to HA hydrogel-based drug delivery systems for targeted therapy of cancer and osteoarthritis. Hyaluronic acid (HA) is a natural, linear, endogenous polysaccharide that plays important physiological and biological roles in the human body. Nowadays, among biopolymers, HA is emerging as an appealing starting material for ...
https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-018-0392-8
Likewise, compact lipid nanostructures and phospholipids including liposomes and micelles are very useful in targeted drug delivery. The use of ideal nano-drug delivery system is decided primarily based on the biophysical and biochemical properties of the targeted drugs being selected for the treatment . However, problems such as toxicity ...
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