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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483039/
Mar 05, 2015 · Polymeric drug delivery systems have been developed to allow controlled local release of biologically active substances for a variety of conditions. Their primary advantages relate to their ability to achieve high local concentrations of active agents while limiting or eliminating systemic toxicities.Author: Scott D. Wait, Roshan S. Prabhu, Stuart H. Burri, Tyler G. Atkins, Anthony L. Asher
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269656/
Brain tumors—particularly glioblastoma multiforme (GBM)—pose an important public health problem in the US. Despite surgical and medical advances, the prognosis for patients with malignant gliomas remains grim: current therapy for is insufficient with nearly universal recurrence. ... New drug delivery strategies are already impacting ...
https://www.sciencedirect.com/science/article/pii/S0168365918302657
In addition, we have outlined strategies that could address GBM drug delivery challenges in Table 4. In our opinion, chemotherapeutic nanomedicine has the ability to address most of the GBM drug delivery challenges, but the extent of its ability to address GBM challenges is still unclear.Author: Lakshmi Pallavi Ganipineni, Fabienne Danhier, Véronique Préat
https://www.tandfonline.com/doi/full/10.3109/21691401.2015.1052467
Oct 03, 2008 · Drug delivery across the BBB: current challenges and limitations. There is an enormous challenge faced by pharmaceutical companies to design and develop targeted therapies that could effectively reach the brain and treat brain diseases such as GBM (Fakhoury et al. 2015 Fakhoury M, Takechi R, Al-Salami H.2015.Author: Marc Fakhoury
https://www.webmd.com/cancer/brain-cancer/what-is-glioblastoma
Glioblastoma is a type of astrocytoma, a cancer that forms from star-shaped cells in the brain called astrocytes. In adults, this cancer usually starts in the cerebrum, the largest part of your brain.Author: Camille Peri
https://pubs.acs.org/doi/10.1021/acs.nanolett.8b04697
This system acted as an active drug delivery platform seeking and specifically targeting glioblastoma cells. It enabled effective delivery of combinational protein and chemotherapeutic drugs by engineered MSC and nanocomposite, respectively. In an in vivo migration model, the hybrid spheroid showed higher nanocomposite retention in the tumor ...Author: Smruthi Suryaprakash, Yeh-Hsing Lao, Hyeon-Yeol Cho, Mingqiang Li, Ha Yeun Ji, Dan Shao, Hanze Hu, C...
https://academic.oup.com/neuro-oncology/article/18/1/27/2509241
Sep 10, 2015 · Treatment of GBM is a formidable challenge. The intense investigation of numerous strategies to improve drug delivery in the context of GBM reflects the difficulty posed by the BBB, which provides both physical and biochemical barriers that limit …Author: Rajneet K. Oberoi, Karen E. Parrish, Terence T. Sio, Rajendar K. Mittapalli, William F. Elmquist, Ja...
https://www.mayoclinic.org/diseases-conditions/glioblastoma/cdc-20350148
Glioblastoma is an aggressive type of cancer that can occur in the brain or spinal cord. Glioblastoma forms from cells called astrocytes that support nerve cells. Glioblastoma can occur at any age, but tends to occur more often in older adults. It can cause worsening headaches, nausea, vomiting and seizures.
https://academic.oup.com/neuro-oncology/article/17/suppl_2/ii9/1073974
Mar 05, 2015 · Polymeric Drug Delivery for Malignant Primary Brain Tumors Introduction and Rationale. Polymeric drug delivery systems have been developed to allow controlled local release of biologically active substances for a variety of conditions.Author: Scott D. Wait, Roshan S. Prabhu, Stuart H. Burri, Tyler G. Atkins, Anthony L. Asher
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