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https://www.cell.com/molecular-therapy-family/methods/fulltext/S2329-0501(16)30165-6
Jan 01, 2016 · Effective cellular internalization of therapeutic genes is a critical process for the successful clinical application of nanoparticles for gene delivery.Author: Jie Chen, Zhaopei Guo, Huayu Tian, Xuesi Chen
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046008/
May 21, 2014 · The use of nanoparticles in gene delivery can provide both the targeted and sustained gene delivery by protecting the gene against nuclease degradation and improving its stability [19-22]. Figure 1 Internalization of non-viral vectors into cell and passage to …Author: Solmaz Maleki Dizaj, Samira Jafari, Ahmad Yari Khosroushahi
https://www.sciencedirect.com/science/article/pii/S0142961211015286
Development of highly efficient nonviral gene delivery vectors still remains a great challenge. In this study, we report a new gene delivery vector based on dendrimer-entrapped gold nanoparticles (Au DENPs) with significantly higher gene transfection efficiency than that of …Author: Yuebin Shan, Yuebin Shan, Ting Luo, Chen Peng, Ruilong Sheng, Amin Cao, Xueyan Cao, Mingwu Shen, Rui...
https://www.nature.com/articles/s41565-020-0669-6?error=cookies_not_supported&code=77395623-c20b-4a56-a39c-72d2c8d16cc2
Sago, C. D. et al. High-throughput in vivo screen of functional mRNA delivery identifies nanoparticles for endothelial cell gene editing. Proc. Natl Acad. Sci. USA 115 , E9944–E9952 (2018).
https://www.researchgate.net/publication/225614430_Drug_and_gene_delivery_using_gold_nanoparticles
Colloidal gold (NPs) has been widely used in different biomedical applications including drug and gene delivery. The aim of this study was to use gold nanoparticles as nanocarriers for targeted...
https://www.sciencedirect.com/science/article/pii/S0169409X02002284
2.4.1. Sustained gene delivery. Rapid escape of nanoparticles from the degradative endo-lysosomal compartment to the cytoplasmic compartment and their sustained intracellular retention suggest that nanoparticles containing encapsulated plasmid DNA could serve as an efficient sustained release gene delivery system . The therapeutic efficacy of the nanoparticles could be due to their ability to protect …Author: Jayanth Panyam, Vinod D Labhasetwar
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822651/
Apr 06, 2016 · Clinical gene therapy using nanoparticles is also hampered by the lack of targeting ability when delivered into the desired diseased tissues. 47,48 To overcome this drawback, the development of specific ligand receptor-mediated active targeting strategy for gene delivery system is critically required.Author: Jie Chen, Zhaopei Guo, Huayu Tian, Xuesi Chen
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801296/
Mar 15, 2016 · Recently, we developed lipid-like nanoparticles that can be synthesized in a combinatorial manner as highly effective protein and gene delivery vehicles (9 –13). We found that electrostatic self-assembly between lipid and protein is essential to form a stable nanocomplex for protein delivery .Author: Ming Wang, John Zuris, Fantao Meng, Holly Anne Rees, Shuo Sun, Pu Deng, Yong Han, Xue Gao, Dimitra P...
https://www.nature.com/articles/gt20175
Jan 17, 2017 · A broad range of dose optima achieve high-level, long-term gene expression after hydrodynamic delivery of sleeping beauty transposons using hyperactive SB100x transposase. Mol Ther Nucleic Acids ...Author: S Guan, J Rosenecker
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527668/
Currently many substances are under investigation for drug delivery and more specifically for cancer therapy. Interestingly pharmaceutical sciences are using nanoparticles to reduce toxicity and side effects of drugs and up to recently did not realize that carrier systems themselves may impose risks to …Author: Wim H De Jong, Paul Ja Borm
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