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https://www.ncbi.nlm.nih.gov/pubmed/29792369
Aug 01, 2018 · Distribution of gene expression within the cell layers of the cornea depended on the composition of the four vectors evaluated. CONCLUSION: Solid lipid nanoparticle-based vectors are promising gene delivery systems for corneal diseases, including inflammation.Author: Mónica Vicente-Pascual, Andrea Albano, María Á Solinís, Loredana Serpe, Alicia Rodríguez-Gascón, Fed...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823390/
Feb 15, 2010 · 3. Gene delivery to the corneal epithelium. Although the outermost corneal epithelium is the most accessible, e.g., to the administration of eye drops, the tight junctions in the epithelium create a major barrier to topical gene delivery [].For the delivery of hydrophilic molecules, the paracellular route of the epithelial layer is the predominant pathway and the permeability is a function of ...Author: Jinsong Hao, S. Kevin Li, Winston W.Y. Kao, Chia-Yang Liu
https://www.sciencedirect.com/science/article/pii/S0361923009001932
This paper reviews the strategies of in vivo gene delivery to the cornea. A number of studies have demonstrated the feasibility of targeted delivery of oligonucleotides, small interfering RNA (siRNA), plasmid DNA, and viral vectors to the corneal cells in vivo, specifically stromal keratocytes and corneal epithelial cells, via intrastromal injection, iontophoresis, electroporation, and gene gun.Author: Jinsong Hao, S. Kevin Li, Winston W.Y. Kao, Chia-Yang Liu
https://www.researchgate.net/publication/26324676_Gene_delivery_to_cornea
This paper reviews the strategies of in vivo gene delivery to the cornea. A number of studies have demonstrated the feasibility of targeted delivery of oligonucleotides, small interfering RNA ...
https://www.atsjournals.org/doi/full/10.1164/ajrccm.162.supplement_3.15tac11
Oct 01, 2000 · Similar data concerning the feasibility of adenoviral gene delivery to the cornea and the anterior chamber have been obtained by other groups . There are several unanswered questions that arise from these preliminary studies. The first concerns the location of gene expression. As described above, expression is seen only in the endothelial layer ...Author: Andrew J. T. George, Carolina V. Arancibia-Cárcamo, Hanna M. Awad, Richard M. Comer, Zoltan Fehevari...
https://www.sciencedirect.com/science/article/pii/S0014483518302884
3.1. Delivery systems (vectors) for gene therapy to the cornea. The most difficult and important challenge in the gene therapy field is delivery. Naked nucleic acids are generally inefficient due to their limited stability, and because their large size and negative charges impair cell internalization.Author: Josune Torrecilla, Ana del Pozo-Rodríguez, Mónica Vicente-Pascual, María Ángeles Solinís, Alicia Rod...
https://www.deepdyve.com/lp/elsevier/gene-delivery-to-cornea-su8EkAS9SE
Feb 15, 2010 · This paper reviews the strategies of in vivo gene delivery to the cornea. A number of studies have demonstrated the feasibility of targeted delivery of oligonucleotides, small interfering RNA (siRNA), plasmid DNA, and viral vectors to the corneal cells in vivo , specifically stromal keratocytes and corneal epithelial cells, via intrastromal injection, iontophoresis, electroporation, and gene ...
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