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https://www.ncbi.nlm.nih.gov/pubmed/17406580
1. Nat Protoc. 2006;1(6):3166-73. Stereotaxic gene delivery in the rodent brain. Cetin A(1), Komai S, Eliava M, Seeburg PH, Osten P. Author information: (1)Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany. Stereotaxic surgery has been an invaluable tool in systems neuroscience, applied in many experiments for the ...Author: Ali Cetin, Shoji Komai, Marina Eliava, Peter H Seeburg, Pavel Osten
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2630580/
Routes of gene delivery: the long and winding road. Many studies have been published regarding delivery of genes to the nervous system. Strength of transgene expression and distribution throughout the brain are dependent on vector backbone, promoters used, and site, volume, and rate of injection.5,6 Different vectors, as well as delivery in various stages of brain development, have been used ...Author: Manfred Schubert, Xandra Breakefield, Howard Federoff, Robert M Frederickson, Pedro R Lowenstein
https://n.neurology.org/content/62/8/1275
Apr 27, 2004 · Gene therapy offers the promise of an effective cure for both genetic and acquired brain disease. However, the limiting problem in brain gene therapy is delivery to brain followed by regulation of the expression of the transgene. Present day gene vectors do not cross the blood-brain barrier (BBB).Author: Felix Schlachetzki, Yun Zhang, Ruben J. Boado, William M. Pardridge
https://www.statnews.com/2016/02/02/virus-blood-brain-barrier-genes/
A method using viruses may be able to deliver therapeutic genes to the brain. Above, green fluorescent protein (GFP) is shown in the mouse cerebellum after the GFP gene is delivered using the method.
https://www.pnas.org/content/102/32/11539
Aug 09, 2005 · Gene delivery into the brain ventricular space has an advantage of minimizing damage of the brain tissue and could potentially allow expression of the transgenes in several brain structures that surround the ventricles and in cells within the ventricular wall. Seven days after the intraventricular injection of DNA-free ORMOSIL nanoparticles, we ...Author: Dhruba J. Bharali, Ilona Klejbor, Ewa K. Stachowiak, Purnendu Dutta, Indrajit Roy, Navjot Kaur, Earl...
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(16)38877-3
May 01, 2009 · Using an in vivo imaging system (IVIS), we assessed the level of luciferase gene activity on days 3 and 7 post-delivery of the DNA nanoparticles. Following IVIS collection on day 7, brain tissue lysates were prepared and used to further assess luciferase expression with …
https://pubs.acs.org/doi/10.1021/acsnano.8b08177
Radiation-Induced Targeted Nanoparticle-Based Gene Delivery for Brain Tumor Therapy Gulsah Erel-Akbaba Experimental Therapeutics and Molecular Imaging Lab, Department of Neurology, Neuro-Oncology Division, Massachusetts General Hospital, Charlestown, Massachusetts 02129, United StatesAuthor: Gulsah Erel-Akbaba, Litia A. Carvalho, Tian Tian, Tian Tian, Max Zinter, Hasan Akbaba, Hasan Akbaba,...
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