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https://link.springer.com/article/10.1023%2FA%3A1007548826495
Feb 01, 2000 · Gene transfer to humans requires carriers for the plasmid DNA which canefficiently and safely carrythe gene into the nucleus of the desired cells. A series of chemically differentcationic polymers arecurrently being investigated for these purposes. Although many cationic polymersindeed condense DNAspontaneously, which is a requirement for gene transfer in most types of cells,the ...Author: Stefaan C. De Smedt, Joseph Demeester, Wim E. Hennink
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481959/
The syntheses and evaluation of bio-reducible polymers for efficient gene delivery systems have been made over the past decade in our laboratory. Up to date, the poly (ethylenimine) (PEI)-conjugated bio-reducible polymers exhibit one of good candidates for the application of cancer gene delivery systems.Author: Yong Kiel Sung, Sung Wan Kim
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294582/
Polymers are synthetic gene delivery vectors which possess the ability to deliver genetic material to target cells [3, 4, 12, 13]. Cationic polymers neutralize the negative charge on plasmid DNA resulting in the formation of nanoscale polymer-DNA complexes (polyplexes).Author: Sutapa Barua, James Ramos, Thrimoorthy Potta, David Taylor, Huang Chiao Huang, Gabriela Montanez, Ka...
https://www.sciencedirect.com/science/article/pii/S0168365918301202
The clinical success of chimeric antigen receptor (CAR) T cell immunotherapy in treating multiple blood cancers has created a need for efficient methods of ex vivo gene delivery to primary human T cells for cell engineering. Here, we synthesize and evaluate a panel of cationic polymers for gene delivery to both cultured and primary human T cells.Author: Brynn R. Olden, Yilong Cheng, Jonathan L. Yu, Suzie H. Pun
https://www.mdpi.com/journal/polymers/special_issues/polymers_in_gene_delivery
In 1987, Felgner et al. used the cationic lipid based non-viral gene delivery system for the very first time. This breakthrough opened the opportunity for other non-viral vectors, such as polymers. Cationic polymers have emerged as promising candidates for non-viral gene delivery systems because of their facile synthesis and flexible properties.
https://pubs.acs.org/doi/abs/10.1021/mp060076n
This review discusses the development of functional and multifunctional dendrimeric and hyperbranched polymers, collectively called dendritic polymers, with the objective of being applied as drug and gene delivery systems. In particular, using as starting materials known and well-characterized basic dendritic polymers, the review deals with the type of structural modifications to which these ...Author: Constantinos M. Paleos, Dimitris Tsiourvas, Zili Sideratou
https://www.sciencedirect.com/topics/materials-science/cationic-polymer
Cationic polymers that have shown significant promise as gene delivery agents are more effective than the state-of-the art, commercially available non-viral systems. Gene delivery in vivo involves interactions with the biophase (the effect site of drug) prior to reaching the target cells which complicates efforts to understand the mechanism of ...
https://biomaterialsres.biomedcentral.com/articles/10.1186/s40824-019-0156-z
Mar 12, 2019 · Gene delivery systems are essentially necessary for the gene therapy of human genetic diseases. Gene therapy is the unique way that is able to use the adjustable gene to cure any disease. The gene therapy is one of promising therapies for a number of diseases such as inherited disorders, viral infection and cancers. The useful results of gene delivery systems depend open the adjustable ...Author: YK Sung, SW Kim
https://www.researchgate.net/publication/226524947_Cationic_Polymer_Based_Gene_Delivery_Systems
Cationic Polymer Based Gene Delivery Systems. ... Among the polymers used for gene delivery research, cationic polymers are gaining more attention due to their ability to condense large nucleic ...
https://www.nature.com/articles/nrd1775
Jul 01, 2005 · Consideration of the important barriers to gene delivery, therefore, is necessary to understand the limitations of cationic polymers and is important for the rational design of new polymers ...Author: Daniel W. Pack, Allan S. Hoffman, Suzie Pun, Patrick S. Stayton
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