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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449975/
Apr 28, 2017 · Another benefit of GO, specific for gene delivery, is its ability to protect nucleotides from cleavage . Kim et al. designed a stimuli-responsive gene delivery vehicle, composed of polyethylene glycol-branched polyethylenimine-reduced graphene oxide (PEG-BPEI-rGO). This stimuli-responsive delivery was accomplished by using near-infrared (NIR) irradiation that, when absorbed by the GO nanoparticles…Author: Michael K. Riley, Wilfred Vermerris
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046008/
May 21, 2014 · Nanoparticles in gene delivery. In the field of nanomedicine, nanotechnology methods focus on formulating therapeutic biocompatible agents such as nanoparticles, nanocapsules, micellar systems, and conjugates [22,23].Nanoparticles are solid and spherical structures ranging to around 100 nm in size and prepared from natural or synthetic polymers [].Author: Solmaz Maleki Dizaj, Samira Jafari, Ahmad Yari Khosroushahi
https://engineering.jhu.edu/materials/research-projects/polymeric-nanoparticles-for-gene-delivery/
Polymeric Nanoparticles for Gene Delivery The aim of this study is to investigate the structure-transfection efficiency relationship of PPA gene carriers; and to investigate the effect of PPA structure on DNA compaction ability of PPA, stability of PPA/DNA nanoparticles in physiological medium, cellular uptake efficiency, intracellular trafficking, DNA unpacking, and nuclear translocation.
https://www.sciencedirect.com/science/article/pii/S0169409X16303167
This highlights an advantage of non-viral gene delivery nanoparticles in that once optimized for delivery to one cell type following a particular route of administration, a plasmid's sequence, including its encoded gene of interest, can be varied without changing the physicochemical properties of the nanoparticle and its intracellular delivery efficacy to that cell type.Author: Jayoung Kim, Adam C. Mirando, Aleksander S. Popel, Jordan J. Green
https://www.cell.com/molecular-therapy-family/methods/fulltext/S2329-0501(16)30165-6
Jan 01, 2016 · Recently, nanoparticles are being investigated to utilize as gene delivery systems to overcome the delivery barriers due to their properties associated with safety, nonimmunogenicity, controllability, and low cost.Author: Jie Chen, Zhaopei Guo, Huayu Tian, Xuesi Chen
https://www.sciencedirect.com/science/article/pii/B9780081005576000043
From these studies, it has been postulated that bioreducible cross-linked polymeric nanoparticles have been shown as efficient and safe gene delivery vehicles because of their stability in an extracellular medium and rapid degradation in a reductive intracellular environment which facilitates release of the bound DNA for nuclear localization.Author: Manohar Mahato, Ashwani Kumar Sharma, Pradeep Kumar
https://www.precisionnanosystems.com/resource-center/publications/detail/microfluidic-generated-lipid-graphene-oxide-nanoparticles-for-gene-delivery
Graphene oxide (GO) is employed in a broad range of biomedical applications including antimicrobial therapies, scaffolds for tissue engineering, and drug delivery, among others. However, the inability to load it efficiently with double-stranded DNA impairs its use as a gene delivery system. To overcome this limitation, in this work, the functionalization of GO with cationic lipids (CL) is ...
https://www.sciencedaily.com/releases/2013/05/130530111153.htm
May 30, 2013 · Stent angioplasty saves lives, but comes with complications. A new nanoparticle gene delivery method will hopefully overcome limitations of gene therapy vectors and prevent complications ...
https://www.intechopen.com/books/advanced-technology-for-delivering-therapeutics/medicated-nanoparticle-for-gene-delivery
In the magnetic nanoparticle gene delivery system, the gene directly binds to the magnetic particle or carrier. In magnetic nanoparticle, a magnetic core is coated by a protective layer either by dispersing in a polymer matrix or encapsulated within a polymer/metallic shell, which can be combined with therapeutic agents (carrier/DNA complexes or other drugs) through covalent or noncovalent bond.Author: Sakthivel Lakshmana Prabu, Timmadonu Narasimman KuppusamiSuriyaprakash, Rathinasabapathy Thirumuruga...
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