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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449975/
Apr 28, 2017 · 4. Proteins and Peptide Nanomaterials for Gene Delivery. Proteins are attractive as gene delivery vectors, because of their biocompatibility, biodegradability and, typically, minimal toxicity . Their amphiphilic nature allows them to interact with both the solvent and the specific cargo (DNA, RNA or therapeutic agent) of choice.Author: Michael K. Riley, Wilfred Vermerris
https://www.ncbi.nlm.nih.gov/pubmed/19488722
The ability to incorporate genetic materials such as plasmid DNA, RNA, and siRNA into functionalized nanoparticles with little toxicity demonstrates a new era in pharmacotherapy for delivering genes selectively to tissues and cells.Author: Sha Jin, John C. Leach, Kaiming Ye
https://www.sciencedirect.com/science/article/pii/S0169409X16303167
Non-viral nanoparticles face several barriers in the process of gene delivery [21]. First, a vector must form a stable complex with the genetic cargo. In the case of polymeric vectors, this is most often achieved through electrostatic interaction between cationic polymer and negatively charged nucleic acids.Author: Jayoung Kim, Adam C. Mirando, Aleksander S. Popel, Jordan J. Green
https://engineering.jhu.edu/materials/research-projects/polymeric-nanoparticles-for-gene-delivery/
The aim of this study is to investigate the structure-transfection efficiency relationship of PPA gene carriers; and to investigate the effect of PPA structure on DNA compaction ability of PPA, stability of PPA/DNA nanoparticles in physiological medium, cellular uptake efficiency, intracellular trafficking, DNA unpacking, and nuclear translocation.
http://onlinelibrary.wiley.com/doi/10.1002/smll.201202485/full
Natalia Voronina, Evgenya Delyagina, Robert David and Gustav Steinhoff, Inorganic nanoparticles for gene delivery, Advances and Challenges in the Delivery of Nucleic Acid Therapeutics (Volume 1), 10.4155/fseb2013.13.106, (108-123), (2015).
https://www.sciencedirect.com/science/article/pii/B9780081005576000043
The success of nonviral gene therapy mainly depends on the design and development of safe and effective gene delivery systems. Nonviral vectors have attracted the attention of researchers, as they offer several advantages over their viral counterparts.Author: Manohar Mahato, Ashwani Kumar Sharma, Pradeep Kumar
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