Gene And Dna Drug Delivery System

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Gene therapy and DNA delivery systems - ScienceDirect

    https://www.sciencedirect.com/science/article/pii/S0378517313010351
    The principle of physical gene delivery systems is to use mechanical, ultrasonic, electric, hydrodynamic or laser-based energy in order to create temporary weak points in the membrane of the target cell, by causing transient injuries or defects in it and allows the DNA to inter the cell by diffusion.Author: D. Ibraheem, A. Elaissari, H. Fessi

Recent advances in the development of gene delivery systems

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417261/
    Mar 12, 2019 · The gene delivery systems consist of the three components such as a plasmid-based gene expression system that controls the function of a gene within the targeting cell, a gene that encodes a specific therapeutic protein, and a gene delivery system that controls the delivery of the gene expression plasmid to specific location within the body [4, 5].Author: YK Sung, SW Kim

GDD NIH Center for Scientific Review

    https://public.csr.nih.gov/StudySections/DBIB/BST/GDD
    The Gene and Drug Delivery Systems (GDD) study section considers grant applications focused on fundamental aspects of gene and drug delivery, including delivery vehicle development, targeting strategies, and biological barriers. Applications are typically focused on bioengineering principles and may not be hypothesis driven.

Viral and nonviral delivery systems for gene delivery

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507026/
    Jul 06, 2012 · Different types of gene delivery systems may be applied in gene therapy to restore a specific gene function or turning off a special gene(s). The ultimate goal of gene therapy is single administration of an appropriate material to replace a defective or missing gene.

Novel gene delivery systems - PubMed Central (PMC)

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3687232/
    Nov 27, 2012 · The viral gene delivery systems include lytic and nonlytic vectors for drug delivery. Inspite of its toxicity they are still preferred because of their long term expression, stability, and integrity. This review explores the recent developments and relevancy of the novel gene delivery systems in gene therapy.

Nanotechnology in Gene and Drug Delivery

    http://www.phys.sinica.edu.tw/TIGP-NANO/Course/2012_Spring/classnotes/NanoB_20120511.pdf
    Non-viral Gene Delivery • Transfection- the delivery of foreign molecules such as DNA and RNA into eukaryotic cells • Naked DNA is not suitable for in-vivo transport of genetic materials-> degradation by serum nucleases • Ideal gene delivery system – Biocompatible – Non-immunogenic – Stable in blood stream – Protect DNA during ...

Gene Delivery Systems: Recent Progress in Viral and Non ...

    https://www.intechopen.com/books/recent-advances-in-novel-drug-carrier-systems/gene-delivery-systems-recent-progress-in-viral-and-non-viral-therapy
    Delivery with gene gun method is also termed ballistic DNA delivery or DNA-coated particle bombardment, and was first used for gene transfer to plants in 1987 (Al-Dosari and Gao, 2009; Lin et al., 2000). This method is based on the principle of delivery of DNA-coated heavy metal particles by crossing them from target tissue at a certain speed.Author: Erdal Cevher, Ali Demir Sezer, Emre Şefik Çağlar

Gene therapy and gene delivery systems - SlideShare

    https://www.slideshare.net/SalmanHashmi10/gene-therapy-and-gene-delivery-systems
    Dec 19, 2014 · Gene therapy and gene delivery systems. 1. GENES • Are carried on a chromosome • The basic unit of heredity • Encode how to make a protein • DNA RNA proteins • Proteins carry out most of life’s function. • When altered causes dysfunction of a protein.

Recent Advances in Nanomaterials for Gene Delivery—A Review

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449975/
    Apr 28, 2017 · Regardless of the vector, there are two main approaches to affecting the genetics of targeted cells: (1) Gene therapy where DNA is delivered with the aim of providing a functional copy of a defective gene in the patient, and (2) The delivery of therapeutic nucleic acids which include microRNA (miRNA), short hairpin RNA (shRNA), antisense oligonucleotides (AONS) and small interfering …Author: Michael K. Riley, Wilfred Vermerris

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