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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3490684/
Liposomal delivery of gemcitabine. Liposomes are biocompatible and biodegradable self-assembled vesicles, characterized by a supramolecular lipidic organization which is the same as that found in the natural membranes of living cells (Figure 2).23 This is an advantage from the standpoint of biocompatibility and biodegradability because it induces neither side effects nor accumulation.Author: Cinzia Federico, Valeria M Morittu, Domenico Britti, Elena Trapasso, Donato Cosco
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815202/
Effective drug delivery in pancreatic cancer treatment remains a major challenge. Because of the high resistance to chemo and radiation therapy, the overall survival rate for pancreatic cancer is extremely low. Recent advances in drug delivery systems hold great promise for improving cancer therapy.
https://www.sciencedirect.com/science/article/pii/S2162253118301306
The main objective of the present study was to develop a method for delivery of the anticancer drug gemcitabine using an oligonucleotide aptamer and evaluate its in vivo antitumor efficacy against pancreatic tumors. Gemcitabine is a deoxycytidine analog that inhibits DNA synthesis via incorporation of its diphosphate metabolite into the DNA strand.Author: Jun Young Park, Ye Lim Cho, Ju Ri Chae, Sung Hwan Moon, Won Gil Cho, Yun Jung Choi, Soo Jin Lee, Won...
https://www.nature.com/articles/ncomms15678
May 30, 2017 · Conjugation of squalene to gemcitabine as unique approach exploiting endogenous lipoproteins for drug delivery. Nat. Commun. 8, 15678 doi: 10.1038/ncomms15678 (2017).Author: Dunja Sobot, Simona Mura, Semen O. Yesylevskyy, Laura Dalbin, Fanny Cayre, Guillaume Bort, Julie Mou...
http://dl.begellhouse.com/journals/3667c4ae6e8fd136,217c5df148f99179,6e5a95a75510f175.html
To improve the safety and efficacy of cytotoxic drugs, several drug delivery systems have been explored. This review outlines the recent work directed toward gemcitabine delivery systems for cancer therapy, including aerosols, polymeric nanoparticles, liposomes, microparticles, carbon nanotubes, and multifunctional theranostic nanomedicines.Author: Sathish Dyawanapelly, Animesh Kumar, Manish K. Chourasia
https://www.sciencedirect.com/science/article/pii/S1742706120300544
The standard chemotherapeutic drug for the first-line treatment of PDA is gemcitabine (GEM), which is a cytidine analogue that inhibits DNA replication . However, its therapeutic effectiveness is hindered by its rapid metabolism through cytidine deaminase (CDA) . Thus, in clinical practice, GEM is often combined with other therapeutics (such as ...Author: Jingjing Sun, Zhuoya Wan, Yichao Chen, Jieni Xu, Zhangyi Luo, Robert A. Parise, Dingwei Diao, Pengfe...
https://www.hindawi.com/journals/tswj/2014/560962/
Gemcitabine (2,2-difluorodeoxycytidine) is a deoxycytidine analog, currently being used as a first-choice drug in pancreatic metastatic cancer. Gemcitabine is administered weekly as 30-minute infusion with starting dose ranging from 800 to 1250 mg/m 2 . The aim of the present work was to develop starch nanoparticles (NPs) for the delivery of gemcitabine hydrochloride that could reduce its dose ...Author: Rekha Khaira, Jyoti Sharma, Vinay Saini
https://www.blinkhealth.com/gemcitabine
Gemcitabine is used to treat certain types of cancer (including breast, lung, ovarian, pancreatic). It is a chemotherapy drug that works by slowing or stopping the growth of cancer cells. ... Home delivery orders may be subject to delays if those pharmacies or prescribers do not immediately respond to requests to transfer prescriptions to Blink ...
https://www.mdpi.com/1420-3049/21/4/522
In this paper, mesoporous silica nanoparticles (MSNs) were studied as vehicles for the delivery of the antitumoral drug gemcitabine (GEM) and of its 4-(N)-acyl derivatives, (4-(N)-valeroyl-(C5GEM), 4-(N)-lauroyl-(C12GEM) and 4-(N)-stearoyl-gemcitabine (C18GEM)). The loading of the GEM lipophilic prodrugs on MSNs was explored with the aim to obtain both a physical and a chemical protection of ...Author: Alessio Malfanti, Ivana Miletto, Emanuela Diana Bottinelli, Daniele Zonari, Giulia Blandino, Gloria ...
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