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https://medium.com/parkinsons-uk/meet-the-team-behind-the-gdnf-trial-ec7f3c2d102c
May 01, 2017 · Meet the team behind the GDNF trial. ... An innovative drug delivery system. To get GDNF to the brain cells that need it, we’re using an innovative delivery system, specially designed for the ...Author: Claire Bale
https://medium.com/parkinsons-uk/gdnf-trial-results-explained-8366de5ee669
Feb 27, 2019 · To address this challenge, neurosurgeon Professor Steven Gill, designed a sophisticated new delivery system. Instead of a slow but constant flow of GDNF, the new delivery system used a …Author: Claire Bale
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6931095/
Glial cell-line-derived neurotrophic factor (GDNF) is a potent neuroprotective agent in cellular and animal models of Parkinson’s disease (PD). However, CNS delivery of GDNF in clinical trials has proven challenging due to blood-brain barrier ...Author: Cang Chen, Michael J. Guderyon, Yang Li, Guo Ge, Anindita Bhattacharjee, Cori Ballard, Zhixu He, Eli...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726227/
We demonstrate that the focused ultrasound-triggered GDNFp-loaded cationic microbubbles platform can achieve non-viral targeted gene delivery via a noninvasive administration route, outperform intracerebral injection in terms of targeted GDNF delivery of high-titer GDNF genes, and has a neuroprotection effect in Parkinson’s disease (PD ...Author: Ching-Hsiang Fan, Chien-Yu Ting, Chung‐Yin Lin, Hong-Lin Chan, Yuan-Chih Chang, You-Yin Chen, Hao-Li...
https://www.cell.com/molecular-therapy-family/methods/fulltext/S2329-0501(19)30138-X
Glial cell-line-derived neurotrophic factor (GDNF) is a potent neuroprotective agent in cellular and animal models of Parkinson’s disease (PD). However, CNS delivery of GDNF in clinical trials has proven challenging due to blood-brain barrier (BBB) impermeability, poor diffusion within brain tissue, and …Author: Cang Chen, Michael J. Guderyon, Yang Li, Guo Ge, Anindita Bhattacharjee, Cori Ballard, Zhixu He, Eli...
https://www.rndsystems.com/resources/artices/gdnf-novel-treatment-parkinson%E2%80%99s-disease
Unfortunately, GDNF delivery in humans by intracerebroventricular injection or intrastriatal infusion has proven ineffective and other methods of GDNF delivery have yet to be tested. 14 Thus, finding a safe and effective approach to exploit the neuroprotective effects of …
https://parkinsonsnewstoday.com/2019/03/04/gdnf-potential-neurorestorative-treatment-parkinsons-disease/
Mar 04, 2019 · Infusion of a naturally occurring protein, GDNF, into a motor control area of the brain may restore cells damaged by Parkinson’s disease and ease patients' symptoms, results from a European clinical trial suggest. The study, “Extended Treatment with …5/5(2)
https://www.michaeljfox.org/grant/intranasal-delivery-gdnf-parkinsons-disease-next-steps
Objective/Rationale: GDNF, a naturally-occurring growth factor capable of protecting and promoting the survival of dopamine neurons, has great potential as a treatment for Parkinson’s disease. However, the delivery of GDNF to the brain has proven to be an insurmountable obstacle. With a Rapid Response Innovation Award from The Michael J. Fox Foundation, we showed that GDNF given intranasally ...
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