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https://ijpras.com/storage/models/article/TeYOGN6dBciE6RSaYCvW8hR2FcFAQVag5S1dwxVGo5yZrYaTt4UG4Qf5nKWQ/gastroretentive-drug-delivery-system-a-review.pdf
such drug delivery system. Floating drug delivery system has a bulk density lower than gastric fluids and thus remain buoyant in the stomach for prolong period of time, without affecting the gastric emptying rate. While the system is floating on the gastric content, the drug is released slowly at a desired rate from the stomach.
https://www.ncbi.nlm.nih.gov/pubmed/9699081
Gastric retentive drug-delivery systems. Hwang SJ(1), Park H, Park K. Author information: (1)Purdue University, School of Pharmacy, West Lafayette, IN 47907, USA. The development of a long-term oral controlled-release dosage form has been difficult mainly because of the transit of the dosage form through the gastrointestinal (GI) tract.Author: Sung Joo Hwang, Haesun Park, Kinam Park
https://www.sciencedirect.com/science/article/pii/S1818087616300320
Gastro-retentive drug delivery system (GRDDS) is one such example where the attribute like gastric retention time coupled with the drug release for extended time has significantly improved patient compliance. Some inherent limitations of the conventional oral drug delivery systems have ignited the interest to this new delivery system.Author: Uttam Kumar Mandal, Bappaditya Chatterjee, Faria Gias Senjoti
https://innovareacademics.in/journal/ajpcr/Vol3Issue1/250.pdf
Floating drug delivery systems Floating drug delivery systems is one of the important approaches to achieve gastric retention to obtain sufficient drug bioavailability [25]. This delivery systems is desirable for drugs with an absorption window in the stomach or in the upper small intestine [26].
https://www.pharmatutor.org/articles/overview-on-gastro-retentive-drug-delivery-system
These drug delivery systems suffer from mainly two adversities: the short gastric retention time(GRT) and unpredictable short gastric emptying time (GET), which can result in incomplete drug release from the dosage form in the absorption zone (stomach or upper part of small intestine) leading to diminished efficacy of administered dose .
http://pharmaquest.weebly.com/uploads/9/9/4/2/9942916/grdds.pdf
Therefore, a system designed for longer gastric retention will extend the time within which drug absorption can occur in the small intestine. Certain types of drugs can benefit from using gastric retentive devices. These include: •Acting locally in the stomach. • Primarily absorbed in the stomach.
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