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https://www.sciencedirect.com/science/article/pii/S1818087616300320
Gastro-retentive drug delivery system (GRDDS) is one such example where the attribute like gastric retention time coupled with the drug release for extended …Author: Uttam Kumar Mandal, Bappaditya Chatterjee, Faria Gias Senjoti
https://www.pharmatutor.org/articles/overview-on-gastro-retentive-drug-delivery-system
These drug delivery systems suffer from mainly two adversities: the short gastric retention time(GRT) and unpredictable short gastric emptying time (GET), which can result in incomplete drug release from the dosage form in the absorption zone (stomach or upper part of small intestine) leading to diminished efficacy of administered dose .
https://ijpras.com/storage/models/article/TeYOGN6dBciE6RSaYCvW8hR2FcFAQVag5S1dwxVGo5yZrYaTt4UG4Qf5nKWQ/gastroretentive-drug-delivery-system-a-review.pdf
such drug delivery system. Floating drug delivery system has a bulk density lower than gastric fluids and thus remain buoyant in the stomach for prolong period of time, without affecting the gastric emptying rate. While the system is floating on the gastric content, the drug is released slowly at a desired rate from the stomach.
https://innovareacademics.in/journal/ajpcr/Vol3Issue1/250.pdf
Floating drug delivery systems Floating drug delivery systems is one of the important approaches to achieve gastric retention to obtain sufficient drug bioavailability [25]. This delivery systems is desirable for drugs with an absorption window in the stomach or in the upper small intestine [26].
http://pharmaquest.weebly.com/uploads/9/9/4/2/9942916/grdds.pdf
Therefore, a system designed for longer gastric retention will extend the time within which drug absorption can occur in the small intestine. Certain types of drugs can benefit from using gastric retentive devices. These include: •Acting locally in the stomach. • Primarily absorbed in the stomach.
http://ijpsr.com/bft-article/gastroretentive-drug-delivery-system-an-approach-to-enhance-gastric-retention-for-prolonged-drug-release/?view=fulltext
Gastroretentive drug delivery system is novel drug delivery systems which has an upper hand owing to its ability of prolonged retaining ability in the stomach and thereby increase gastric residence time of drugs and also improves bioavailability of drugs.
https://www.slideshare.net/ShwetaNehate/gastro-retentive-drug-delivery-system-ppt-grdds
Mar 20, 2018 · Gastro-retentive drug delivery system (GRDDS) has gainned immense popularity in the field of oral drug delivery recently. it is a widely employed approach to retain the dosage form in the stomach for an extended period of time and release the drug slowly that can address many challenges associated with conventional oral delivery, including poor bioavailability. different innovative …
http://idosi.org/ajbas/ajbas3%286%2911/8.pdf
Gastro retentive drug delivery systems prolong the time, while the neonates and children have low dosing intervals and thus improve patient compliance. gastric retention time, in comparison to a normal Presence of drug in solution form is the most essential adult. requisite for a drug to get absorbed.
https://www.slideshare.net/akashaher07/1-gastroretentive-drug-delivery-systems
Jun 08, 2013 · ConclusionGastro retentive drug delivery systems are the mostpreferable systems in order to deliver the drugs whichhave a narrow absorption window near the gastricregion. Now a days a number of drug delivery devicesare being developed which aim at releasing the drug atgastric region.
http://www.authorstream.com/Presentation/johnnybravo8456-1164523-gastro-retentive-drug-delivery-system/
Aug 27, 2011 · DEFINITION These are the drug delivery systems which possess the ability of retaining the drug in the GIT particularly in the stomach for prolonged period of time. After the drug release for required time period the dosage form should get degraded without causing any gastric disturbances. NEED FOR GASTRO RETENTION:
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