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https://www.sciencedirect.com/science/article/pii/S0168365913003519
Nov 10, 2013 · Targeted delivery of anti-cancer agents to cancer cells is a mature line of investigation that has yet to realize its full potential. In this study we report on the development of a delivery platform with the future goal of merging two thus far parallel methods for selective elimination of cancer cells: targeted nanospheres and pretargeted radioimmunotherapy.Author: Jared Bushman, Asa Vaughan, Larisa Sheihet, Zheng Zhang, Marius Costache, Joachim Kohn
https://www.researchgate.net/publication/241693070_Functionalized_Nanospheres_for_Targeted_Delivery_of_Paclitaxel
Functionalized Nanospheres for Targeted Delivery of Paclitaxel. Article (PDF Available) in Journal of Controlled Release 171(3) · June 2013 with 45 Reads How we measure 'reads'
https://www.sciencedirect.com/science/article/abs/pii/S0168365913003519
Targeted delivery of anti-cancer agents to cancer cells is a mature line of investigation that has yet to realize its full potential. In this study we…Author: Jared Bushman, Asa Vaughan, Larisa Sheihet, Zheng Zhang, Marius Costache, Joachim Kohn
https://core.ac.uk/download/pdf/82371879.pdf
Functionalized nanospheres for targeted delivery of paclitaxel Jared Bushman, Asa Vaughan, Larisa Sheihet, Zheng Zhang, Marius Costache, Joachim Kohn⁎ New Jersey Center for Biomaterials and Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, 145 Bevier Road, Piscataway, NJ 08854, USA article info abstract
https://www.hindawi.com/journals/bmri/2019/2928507/
Hyaluronic acid functionalized mesoporous hollow alumina nanoparticles (HMHA) were used as a tumor-targeted delivery carrier for liver cancer therapy. Paclitaxel (PAC) incorporated in the carrier by the adsorption method was analyzed by X-ray diffraction and differential scanning calorimetry. PAC was found to be in an amorphous state. The hyaluronic acid coated on the surface of mesoporous ...Author: Yu Gao, Lili Hu, Ying Liu, Xiaoyan Xu, Chao Wu
http://downloads.hindawi.com/journals/bmri/2019/2928507.pdf
Targeted Delivery of Paclitaxel in Liver Cancer Using Hyaluronic Acid Functionalized Mesoporous Hollow Alumina Nanoparticles YuGao ,1 LiliHu,2 YingLiu,2 XiaoyanXu,2 andChaoWu 2 ... nanospheres were synthesized according to the previous reports []. Briey, TPOS (.mL) was dripped into aAuthor: Yu Gao, Lili Hu, Ying Liu, Xiaoyan Xu, Chao Wu
https://journals.sagepub.com/doi/full/10.1177/0885328219896457
Preparation of paclitaxel-folic acid functionalized gelatin grafted mesoporous hollow carbon nanospheres for enhancing antitumor effects toward liver cancer (SMMC-7721) cell lines. ... Folate-conjugated, mesoporous silica functionalized boron nitride nanospheres for targeted delivery of doxorubicin.Author: Yu Gao, Tao Liu, Xuan Liu, Chao Wu
https://core.ac.uk/display/82371879
Targeted nanospheres achieved the half maximal inhibitory concentration of PTX on SUM159 cells at a 5–10 fold lower concentration than that of PTX applied in either non-targeted nanospheres or free drug approaches. Moreover, targeted nanospheres selectively eliminated CD44 positive SUM159 cells compared to free PTX and untargeted nanospheres.Author: Jared Bushman, Asa Vaughan, Larisa Sheihet, Zheng Zhang, Marius Costache, Joachim Kohn
https://pubs.acs.org/doi/10.1021/ja075181k
Aug 24, 2007 · Here we describe the first example of 2 nm gold nanoparticles (Au NPs) covalently functionalized with a chemotherapeutic drug, paclitaxel. The synthetic strategy involves the attachment of a flexible hexaethylene glycol linker at the C-7 position of paclitaxel followed by coupling of the resulting linear analogue to phenol-terminated gold nanocrystals. The reaction proceeds under mild ...Author: Jacob D. Gibson, Bishnu P. Khanal, Eugene R. Zubarev
https://pubs.acs.org/doi/10.1021/bm050212u
The nanosphere−paclitaxel complexes retain in vitro the high antiproliferative activity of paclitaxel, demonstrating that these nanospheres may be useful for delivery of the hydrophobic drugs. ... Functionalized nanospheres for targeted delivery of paclitaxel. Jared …Author: Larisa Sheihet, Robert A. Dubin, David Devore, Joachim Kohn
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