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http://ijpsr.com/bft-article/formulation-and-evaluation-of-controlled-porosity-osmotic-drug-delivery-system-of-metoprolol-succinate/?view=fulltext
In the present study, solubility of metoprolol succinate was retarded with addition of hypromellose in the system. Hypromellose reduce its solubility and dissolution by swelling matrix mechanism. Prepared osmotic tablet of metoprolol succinate gives drug release for up to 24 hr. by combine matrix and osmotic mechanism.
http://etheses.saurashtrauniversity.edu/942/
Formulation, Development, Evaluation, Osmotic, Drug, System: Dewey Decimal Subjects: 600 Technology > 610 Medicine & health > 615 Pharmacology & therapeutics: Library of Congress Subjects: R Medicine > RS Pharmacy and materia medica: Department: Faculties > Science > Department of Pharmaceutical Science: Affiliation with: Saurashtra University: Qualification Level
http://sphinxsai.com/PTVOL4/pdf_vol4/PT=111%20(1638-1643).pdf
No changes in the endotherms were observed as the drug exhibited a sharp melting endotherm in the core and coated formulation. Drug Content and Physical Evaluation:The assay of drug in various formulations varied between 98.6% and 101.5% (mean 100.05%).
https://www.researchgate.net/publication/289351660_Formulation_and_evaluation_of_osmotic_drug_delivery_system_of_ibuprofen
Formulation and evaluation of osmotic drug delivery system of ibuprofen How we measure 'reads' A 'read' is counted each time someone views a publication summary (such as the title, abstract, and...
https://www.researchgate.net/publication/286878491_Formulation_and_in-vitro_evaluation_of_osmotic_drug_delivery_system_of_Metoprolol_succinate
Osmotic drug delivery systems release the drug with the zero order kinetics which does not depend on the initial concentration and the physiological factors of GIT.
https://www.pharmatutor.org/articles/formulation-evaluation-controlled-release-tablets-metoprolol-succinate-osmotic-drug-delivery
The pump consists of an osmotic core containing the drug, surrounded by a semipermeable membrane with a delivery orifice. When this pump is exposed to water, the core imbibes water osmotically at a controlled rate, determined by the membrane permeability to water and by the osmotic pressure of the core formulation.Author: P Deepthi, M Samatha, N Srinivas
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