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https://wikem.org/wiki/Intrathecal_drug_delivery_systems_complication
Used for delivery of short or long acting pain or anti-spasmodic medications into the thecal space Allows for smaller doses and fewer systemic side effects Most common Intrathecal medications
https://neurosurgery.directory/2019/04/05/intrathecal-drug-delivery-device-infection/
Apr 13, 2019 · Intrathecal Drug Delivery Device Infection A major complication of Intrathecal Drug Delivery Device (IDDD) implantationis infection. Morgalla et al., assessed IDD-related complications in 51 patients who had IDD systems implanted for the treatment of chronic pain or spasticity. Twelve patients (23.5%) presented a total of 22 complications.
https://www.sciencedirect.com/science/article/pii/S0169409X20300120
Intrathecal (IT) administration, i.e., the injection of substances directly into cerebrospinal fluid (CSF) that fills the thecal sac, is a potentially powerful drug delivery approach. This route of administration can achieve a high concentration of therapeutic agent within the central nervous system (CNS) while minimizing off-target exposure and associated toxicity [ 1 ].Author: M.J. Fowler, J.D. Cotter, B.E. Knight, E.M. Sevick-Muraca, D.I. Sandberg, D.I. Sandberg, R.W. Sirian...
https://academic.oup.com/bjaed/article/14/1/27/336442
Sep 04, 2013 · Intrathecal drug delivery (ITDD) systems comprise an IT catheter connected to a drug reservoir, which may be externalized and connected to a pump, or fully implanted. Two groups of patients may benefit from ITDD: those with spasticity (baclofen) and those with refractory pain.Author: Louise Lynch
https://en.wikipedia.org/wiki/Nusinersen
The drug is used to treat spinal muscular atrophy associated with a mutation in the SMN1 gene. It is administered directly to the central nervous system (CNS) using intrathecal injection. In clinical trials, the drug halted the disease progression. In around 60% of infants affected by type 1 spinal muscular atrophy, it improves motor function.Other names: IONIS-SMNRx, ISIS-SMNRx
https://en.wikipedia.org/wiki/Drug_delivery
Drug delivery is often approached via a drug's chemical formulation, but it may also involve medical devices or drug-device combination products. Drug delivery is a concept heavily integrated with dosage form and route of administration, the latter sometimes even being considered part of the definition.
https://en.wikipedia.org/wiki/Epidural
Epidural administration (from Ancient Greek ἐπί, "on, upon" + dura mater) is a medical route of administration in which a drug such as epidural analgesia and epidural anaesthesia or contrast agent is injected into the epidural space around the spinal cord.
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