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http://www.eurekaselect.com/openurl/content.php?genre=article&issn=1570-162X&volume=10&issue=1&spage=88
Studies have begun to incorporate scientific strategies into the formulation design of microbicide products in order to develop safer and more effective products. In addition advanced drug delivery strategies to overcome barriers to delivery and specific drug targeting methods are being employed.
https://www.sciencedirect.com/science/article/pii/S0168365914006427
The main purpose behind the formulation of rectal microbicides is to provide adequate vehicles that can properly deliver an active pharmaceutical ingredient (API) to the site of action for a defined period of time in order to elicit protection from HIV infection.Author: Rute Nunes, Bruno Sarmento, José das Neves
https://insights.ovid.com/hiv-aids/cohiv/2008/09/000/microbicide-delivery-formulation-technologies/7/01222929
Recent findings Although early microbicide formulations were conventionally coitally dependent gel products, new technologies are being developed for vaginal delivery of anti-HIV agents. Intravaginal rings for delivery of microbicides, for example, are being developed and evaluated clinically.Author: Joseph Romano, R Malcolm, Sanjay Garg, Lisa Rohan, Paulina Kaptur
http://journals.lww.com/co-hivandaids/Abstract/2008/09000/Microbicide_delivery__formulation_technologies_and.7.aspx
Although early microbicide formulations were conventionally coitally dependent gel products, new technologies are being developed for vaginal delivery of anti-HIV agents. Intravaginal rings for delivery of microbicides, for example, are being developed and evaluated clinically.
https://www.researchgate.net/publication/265726884_Formulation_and_delivery_of_anti-HIV_rectal_microbicides_Advances_and_challenges
This review provides a synopsis of the field of rectal microbicides, namely past and ongoing clinical studies, and details on formulation and drug delivery issues regarding the specific development...
https://www.liebertpub.com/doi/10.1089/108729103322277402
Jul 05, 2004 · Microbicides are being developed as a new therapeutic category for prevention of transmission of sexually transmitted infections (STIs) and HIV. Many of the microbicide formulations (MF) may fail to elicit a protective response either because of a lack of efficacy or inadequate formulation.Author: Sanjay Garg, Kaustubh R. Tambwekar, Kavita Vermani, Raghupathi Kandarapu, Alka Garg, Donald P. Walle...
https://www.liebertpub.com/doi/abs/10.1089/108729103321042881
Microbicides, the compounds and formulations that can prevent transmission of sexually transmitted diseases (STDs)/HIV are being pursued actively as a promising AIDS intervention. The drug development chain for a topical microbicide differs significantly from that of any systemic or topical compound/formulation regarding to time line, cost, activities, and milestones.Author: Sanjay Garg, Raghupathi Kandarapu, Kavita Vermani, Kaustubh R. Tambwekar, Alka Garg, Donald P. Walle...
https://www.researchgate.net/publication/221807104_Formulation_pharmacokinetics_and_pharmacodynamics_of_topical_microbicides
Apr 18, 2011 · This review provides a synopsis of the field of rectal microbicides, namely past and ongoing clinical studies, and details on formulation and drug delivery issues …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460795/
Although these hydrogel formulations provide a familiar inexpensive dosage form for vaginal delivery of microbicide drug candidates, one drawback for these formulations is that they can be associated with leaking and messiness. Liposomal formulations may provide an alternative to traditional gel products. OG is poorly soluble in water.Author: Lin Wang, Alexandra Beumer Sassi, Dorothy Patton, Charles Isaacs, B. J. Moncla, Phalguni Gupta, Lisa...
https://www.crcpress.com/Drug-Delivery-and-Development-of-Anti-HIV-Microbicides/das-Neves-Sarmento/p/book/9789814463560
This book provides for the first time a thorough and critical overview of current aspects, recent developments, and trends in the formulation and drug delivery concerning anti-HIV microbicides by leading scientists in the field. Additionally, pertinent regulatory aspects and socioeconomical issues related to the subject are discussed.
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