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https://www.ncbi.nlm.nih.gov/pubmed/16839640
Aug 07, 2006 · Formulation and delivery issues for monoclonal antibody therapeutics. Daugherty AL(1), Mrsny RJ. Author information: (1)Genentech, Inc., 1 DNA Way South San Francisco, CA 94080, USA. [email protected] Antibodies can have exquisite specificity of target recognition and thus generate highly selective outcomes following their systemic administration.Author: Ann L. Daugherty, Randall J. Mrsny
https://www.sciencedirect.com/science/article/pii/S0169409X06000895
7. Other delivery issues. A wide range of novel drugs and drug conjugates are being developed using monoclonal antibodies and engineered antibody fragments . For some of these novel therapeutic approaches to be successful, they require additional or non-traditional delivery strategies.Author: Ann L. Daugherty, Randall J. Mrsny
https://www.sciencedirect.com/science/article/abs/pii/S0169409X06000895
Fortunately, advances in production and purification capacities have allowed for the exceptionally large amounts of highly purified monoclonal antibodies to be produced. Additionally, genetic engineering of antibodies has provided a stable of antibody-like proteins that can be easier to prepare.Author: Ann L. Daugherty, Randall J. Mrsny
https://rd.springer.com/chapter/10.1007/978-0-387-76643-0_8
Oct 10, 2009 · Kawade Y (1985) Neutralization of activity of effector protein by monoclonal antibody: formulation of antibody dose-dependence of neutralization for an equilibrium system of antibody, effector, and its cellular receptor.Author: Ann L. Daugherty, Randall J. Mrsny
https://researchportal.bath.ac.uk/en/publications/formulation-and-delivery-issues-for-monoclonal-antibody-therapeut
Formulation and delivery issues for monoclonal antibody therapeutics. Advanced Drug Delivery Reviews, 58(5-6), 686-706. ... T1 - Formulation and delivery issues for monoclonal antibody therapeutics. AU - Daugherty, A L. AU - Mrsny, R J. PY - 2006. Y1 - 2006. U2 - 10.1016/j.addr.2006.03.011.Author: Ann L. Daugherty, Randall J. Mrsny
https://www.researchgate.net/publication/290271044_Formulation_and_Delivery_Issues_for_Monoclonal_Antibody_Therapeutics
Monoclonal antibodies (mAbs) are the fastest-growing biological therapeutics with important applications ranging from cancers, autoimmunity diseases and metabolic disorders to …
https://www.infona.pl/resource/bwmeta1.element.elsevier-ad831120-556d-306d-a7db-1b7289154691
Antibodies can have exquisite specificity of target recognition and thus generate highly selective outcomes following their systemic administration. While antibodies can have high specificity, the doses required to treat patients, particularly for a chronic condition, are typically large.
https://www.researchgate.net/publication/6945328_Daugherty_AL_Mrsny_RJ_Formulation_and_delivery_issues_for_monoclonal_antibody_therapeutics_Adv_Drug_Deliv_Rev_58_686-706
Formulation and delivery of proteins and peptides, such as monoclonal antibodies, aptamers, recombinant proteins and peptides to ocular tissues poses significant challenges owing to their large...
https://www.nature.com/articles/nrd4363
Aug 08, 2014 · The formulation and delivery of biopharmaceutical drugs, such as monoclonal antibodies and recombinant proteins, poses substantial challenges owing to their large size and susceptibility to degradation.Author: Samir Mitragotri, Paul A. Burke, Robert Langer
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