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delivered via EKOS over 12-24 hours - Difference in RV/LV ratio from baseline to 48 ± 6 hours - Major bleeding within 72 hours - RV/LV ratio mean difference 0.42 ± 0.36, p <0.0001 - 14 major bleeding events - Small population - Short follow -up - Lack of comparator - …
https://natfonline.org/wp-content/uploads/2017/12/EKOS%C2%AE-Catheter-Article.pdf
2. rtPA was reduced to 0.5 mg / h after four hours. 3. The average thrombolytic time was 14.2 hours. 4. At the end, EKOS® devices were removed. Standardized anticoagulation was administered. Key results 1. Complete resolution of cardiac dysfunction was observed in 64% of patients immediately following the procedure 2.
http://www.moshp.org/resources/Documents/ResidencyConference-2020/presentations/Anticoagulation%2001%20-%20Kirsten%20Robles%20-%20Robles_STLCOP%20Research%20Symposium%20Final.pdf
delivered via EKOS over 12-24 hours - Difference in RV/LV ratio from baseline to 48 ± 6 hours - Major bleeding within 72 hours - RV/LV ratio mean difference 0.42 ± 0.36, p <0.0001 - 14 major bleeding events - Small population - Short follow -up - Lack of comparator - No follow-up of 35 patients in trial. OPTALYSE.
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https://foursquare.com/v/ekos-krib/4cc122e2ed033704cc75ac23
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https://www.bostonscientific.com/en-US/products/thrombectomy-systems/ekosonic-endovascular-system/clinical-evidence.html
EKOS has been shown to yield safe and effective results for acute, massive and submassive PE. Reduces RV/LV ratio by more than 23% on average in as little as 2 hours Reduces PA pressures by 28% (at 48 hours)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957043/
CDT with heparin utilizing EKOS® in patients with submassive PE was shown to decrease the RV/LV ratio within 24 hours of treatment. Additionally, a significant recovery of right ventricular systolic function was observed in the catheter-directed group when compared to heparin only group.
https://www.rsfh.com/clinicalorders/Orders/1292-6586%20Alteplase%20(activase)%20tPA%20via%20EKOS%20for%20Submassive%20Pulmonary%20Embolism%20(PE)%20Binder.pdf
Infuse via EKOS catheter in the PA at 1 mg/hr (10 mL/hr) x 5 hr, then decrease to 0.5 mg/hr (5 mL/hr) x 10 hr, then stop.
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