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https://pubmed.ncbi.nlm.nih.gov/32992998/
With advancing age, the skeletal muscle extracellular matrix (ECM) undergoes fibrotic changes that may lead to increased muscle stiffness, injury susceptibility and strength loss. This study tested the potential of different exercises to counter these changes by stimulating the …
https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fj.14-266668
This study determined the contribution of extracellular matrix (ECM) remodeling to the protective adaptation of human skeletal muscle known as the repeated-bout effect (RBE). Muscle biopsies were obtained 3 hours, 2 days, and 27 days following an initial bout (B1) of lengthening contractions (LCs) and 2 days following a repeated bout (B2) in 2 separate studies.
https://www.mdpi.com/1422-0067/21/19/7089/htm
In conclusion, our study provides data reflecting the effectiveness of different exercise stimuli on the mRNA level of genes associated with skeletal muscle ECM remodeling in elderly men. Six hours after exercise, significant differences were found in the expressions of MMP3, MMP15 and TIMP1, with the greatest responses in MMP3 and TIMP1 seen after conventional resistance exercise followed by foam …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225943/
The extracellular matrix (ECM) serves diverse functions and is a major component of the cellular microenvironment. The ECM is a highly dynamic structure, constantly undergoing a remodeling process where ECM components are deposited, degraded, or otherwise modified. ECM dynamics are indispensible during restructuring of tissue architecture.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316204/
The extracellular matrix (ECM) is a highly dynamic structure that is present in all tissues and continuously undergoes controlled remodelling. This process involves quantitative and qualitative changes in the ECM, mediated by specific enzymes that are responsible for ECM degradation, such as metalloproteinases.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046088/
Dynamic remodeling of the extracellular matrix (ECM) is essential for development, wound healing and normal organ homeostasis. Life-threatening pathological conditions arise when ECM remodeling becomes excessive or uncontrolled. In this Perspective, we focus on how ECM remodeling contributes to ...
https://www.science.org/doi/10.1126/sciadv.abf2629
Cell traction and ECM remodeling are continuous interdependent processes. We have tested the sensor for time-lapse force imaging of single and multiple cells for durations of at least 16 hours. We imaged every 5 min for temporal variations in force.
https://www.liebertpub.com/doi/10.1089/ten.TEB.2021.0066
This reciprocal cell-ECM interaction is crucial for the conservation of cell and tissue functions and homeostasis. In vitro ECM remodeling also plays a key role in regulating the lineage fate of SCs. A deeper understanding of in vitro ECM remodeling may provide new perspectives for the maintenance of SC function.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393593/
Considering the fact that ECM plays a crucial role in the regulation of molecular and cellular response to cardiac muscle ischemic injury and ischemia (infarction)-induced cardiac remodeling, the search for new possible therapeutic approaches targeting ECM in patients with MI seems to be of great importance.
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