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http://www.biologydiscussion.com/gene/therapy/gene-therapy-ex-vivo-and-in-vivo-gene-therapy-with-diagram/9969
II. In vivo gene therapy: The direct delivery of genes into the cells of a particular tissue is referred to as in vivo gene therapy. Type # I. Ex Vivo Gene Therapy: The ex vivo gene therapy can be applied to only selected tissues (e.g., bone marrow) whose cells can be cultured in the laboratory.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584901/
Jun 18, 2019 · While most direct methods of delivery are difficult to utilize in vivo, they can be used to introduce CRISPR/Cas components ex vivo to cells harvested from patients, before reintroducing them into the patient. Notable examples are hematopoietic cells for treatment of sickle-cell anemia, chimeric antigen receptor (CAR) T cells, and germline cells.Author: Danny Wilbie, Johanna Walther, Enrico Mastrobattista
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901163/
Efficient ex vivo gene delivery to cell cultures enables manipulation of cells at the gene-level in biological microelectromechanical systems (BioMEMS), enabling high-throughput and/or real-time study of cellular functions at the molecular level. 39 For example, ...Author: Shan Gao, Erkin Seker, Monica Casali, Fangjing Wang, Shyam Sundhar Bale, Gavrielle M. Price, Martin ...
https://www.nature.com/articles/s41598-019-43737-y
May 29, 2019 · Gene delivery of adenoviral vector during ex vivo normothermic perfusion and heterotopic heart transplant. The overall experimental strategy …Author: Muath Bishawi, Jun Neng Roan, Jun Neng Roan, Carmelo A. Milano, Mani A. Daneshmand, Jacob N. Schrode...
https://seekingalpha.com/article/4305556-gene-therapy-series-2-delivery-systems-in-gene-therapy-including-viral-vectors
Nov 11, 2019 · Examples of gene therapy methods using ex vivo delivery include CAR-T therapies like Yescarta and Kymriah. In vivo delivery: By definition, this …
https://www.researchgate.net/post/What_is_the_difference_between_Ex_vivo_and_In_vitro
Ex vivo means that something is experimented on or investigated outside its natural in vivo environment while in vitro means in the test tube. Eg. ex vivo gene therapy means that cells are taken ...
https://news.ucr.edu/articles/2020/02/20/highlander-venture-fund-invests-basilard-biotech
Basilard is developing a disruptive nanomechanical gene delivery platform, SoloPore, that will transform the engineering of ex vivo cell and gene therapies. The SoloPore technology is based on National Institutes of Health and UC Riverside-funded research performed in the laboratory of mechanical engineering professor Masaru Rao.
https://www.sciencedirect.com/topics/neuroscience/in-vivo-gene-transfer
In vivo gene transfer has an advantage over ex vivo strategies in that it avoids the cumbersome (and costly) process of removing cells from the patient, manipulating the cells in vitro, and returning the genetically modified cells to the patient.
https://www.nature.com/articles/s41598-020-61518-w
Mar 11, 2020 · Ex-vivo gene therapy using stem cells or T cells transduced by retroviral or lentiviral vectors has shown remarkable efficacy in the treatment of immunodeficiencies and cancer. However, the ...Author: Cort B Breuer, Killian S Hanlon, Jeya-Shree Natasan, Adrienn Volak, Amine Meliani, Amine Meliani, Fe...
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