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https://www.ncbi.nlm.nih.gov/pubmed/20227407
Ex vivo delivery of GDNF maintains motor function and prevents neuronal loss in a transgenic mouse model of Huntington's disease. Ebert AD(1), Barber AE, Heins BM, Svendsen CN. Author information: (1)Stem Cell and Regenerative Medicine Center, University of Wisconsin-Madison, 1111 Highland Ave., Madison, WI 53705, USA. [email protected]: Allison D. Ebert, Amelia E. Barber, Brittany M. Heins, Clive N. Svendsen
https://www.ncbi.nlm.nih.gov/pubmed/16324109
Ex vivo gene delivery of GDNF using primary astrocytes transduced with a lentiviral vector provides neuroprotection in a rat model of Parkinson's disease. Ericson C(1), Georgievska B, Lundberg C. Author information: (1)Wallenberg Neuroscience Center, BMC A11, 221 84 Lund, Sweden.Author: Cecilia Ericson, Biljana Georgievska, Cecilia Lundberg
https://www.nature.com/articles/s41434-018-0050-7
Nov 21, 2018 · Thus, our study demonstrates that focal unilateral delivery of neurotrophic factors, such as GDNF, using ex vivo gene therapy based on ECB devices could be …Author: Avtandil Nanobashvili, Esbjörn Melin, Dwaine Emerich, Jens Tornøe, Michele Simonato, Michele Simonat...
https://www.sciencedirect.com/science/article/pii/S2213671118301516
We show that dox administration can inducibly and reversibly modulate GDNF secretion in vivo. As such, we demonstrate that the powerful technologies of iPSCs, ex vivo cell engineering, and gene regulation can be combined as a unique approach to treat disorders where regulated protein delivery …Author: Aslam Abbasi Akhtar, Genevieve Gowing, Naomi Kobritz, Steve E. Savinoff, Leslie Garcia, David Saxon,...
https://www.sciencedirect.com/science/article/pii/S0014488610000749
Direct viral delivery of GDNF and the related molecule neurturin have shown to be potent neuroprotective agents in models of HD (McBride et al., 2006, McBride et al., 2003, Ramaswamy et al., 2009, Ramaswamy et al., 2007). To our knowledge, our data are the first to show a protective effect by GDNF ex vivo gene therapy.Author: Allison D. Ebert, Amelia E. Barber, Brittany M. Heins, Clive N. Svendsen
https://www.researchgate.net/publication/41942926_Ex_vivo_delivery_of_GDNF_maintains_motor_function_and_prevents_neuronal_loss_in_a_transgenic_mouse_model_of_Huntington's_disease
Ex vivo delivery of GDNF also reduced neuronal death and maintained motor functions, although to a lesser extent. This was attributable to lower levels of transgene expression compared to those ...
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(16)31989-X
We then tested the efficacy of a combined ex vivo delivery of GDNF and VEGF in extending survival and protecting neuromuscular junctions (NMJs) and motor neurons. Interestingly, the combined delivery of these neurotrophic factors showed a strong synergistic effect.Author: Dan Krakora, Patrick Mulcrone, Michael Meyer, Christina Lewis, Ksenija Bernau, Genevieve Gowing, Gen...
http://europepmc.org/abstract/MED/16324109
Jan 01, 2006 · Astrocytes are, as normal constituents of the brain, promising vehicles for ex vivo gene delivery to the central nervous system. In the present study, we have used a lentiviral vector encoding glial cell line-derived neurotrophic factor (GDNF) to transduce rat-derived primary astrocytes, in order to evaluate their potential for long-term transgene expression in vivo and neuroprotection in a ...Author: Cecilia Ericson, Biljana Georgievska, Cecilia Lundberg
https://www.researchgate.net/publication/7445294_Ex_vivo_gene_delivery_of_GDNF_using_primary_astrocytes_transduced_with_a_lentiviral_vector_provides_neuroprotection_in_a_rat_model_of_Parkinson's_disease
Ex vivo gene delivery of GDNF using primary astrocytes transduced with a lentiviral vector provides neuroprotection in a rat model of Parkinson's disease
https://www.liebertpub.com/doi/abs/10.1089/10430349950017536
Effects of ex vivo GDNF gene delivery on the degeneration of motoneurons were studied in the G1H transgenic mouse model of familial ALS carrying a human superoxide dismutase (SOD1) with a Gly93Ala mutation (Gurney et al., 1994).Author: M. Hasan Mohajeri, M. Hasan Mohajeri, Denise A. Figlewicz, Martha C. Bohn
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