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https://www.ncbi.nlm.nih.gov/pubmed/11338926
Developing a non-viral gene delivery system that functions in vivo raises the challenge of finding solutions to efficiently deliver DNA to the cell surface that are also compatible with the efficient release of DNA into the cytosol.Author: Kwok Ky, Yang Y, Rice Kg
https://www.sciencedirect.com/science/article/pii/S095816690200294X
Apr 01, 2002 · Non-viral gene delivery systems have the potential to create viable pharmaceuticals from nucleic acids. These DNA delivery systems contain lipids and/or cationic polymers. In order for these systems to be developed into commercial products, several barriers must be overcome. These include obstacles in manufacturing, formulation and stability.Author: Mark E Davis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507026/
Jul 06, 2012 · Although numerous viral and nonviral gene delivery systems have been developed in the last 3 decades, no delivery system has been designed that can be applied in gene therapy of all kinds of cell types in vitro and in vivo with no limitation and side effects.
https://onlinelibrary.wiley.com/doi/10.1002/jgm.3090
As the most efficient gene delivery system in the natural world, viruses have evolved a variety of elegant mechanisms and employ a multistep process to transfer their genomic materials, including targeting cell recognition, cellular binding, endocytosis, penetration, uncoating/disassociation and nuclear import. 1, 2 All of the steps are well‐preprogrammed, precisely triggered by the cues from …Author: Tianying Luo, Hong Liang, Rongrong Jin, Yu Nie
https://www.sciencedirect.com/science/article/pii/S2468451118300254
Non-viral gene delivery via the oral route is a promising strategy for improving outcomes of DNA vaccination and gene therapy applications. Unlike traditional parenteral administration routes, the oral route is a non-invasive approach that lends itself to high patient compliance and ease of dosing.Author: Eric Farris, Kari Heck, Anna T. Lampe, Deborah M. Brown, Amanda E. Ramer-Tait, Angela K. Pannier
http://onlinelibrary.wiley.com/doi/10.1211/002235703765951311/abstract
Feb 18, 2010 · Clinical success of gene therapy based on oligonucleotides (ODNs), ribozymes, RNA and DNA will be greatly dependent on the availability of effective delivery systems. Polycations have gained increasing attention as a non-viral gene delivery vector in the past decades.
https://www.researchgate.net/publication/7048429_Two_novel_non-viral_gene_delivery_vectors_Low_molecular_weight_polyethylenimine_cross-linked_by_2-hydroxypropyl-b-cyclodextrin_or_2-hydroxypropyl-g-cyclodextrin
Two novel non-viral gene delivery vectors: Low molecular weight polyethylenimine cross-linked by (2-hydroxypropyl)-β-cyclodextrin or (2-hydroxypropyl)-γ-cyclodextrin
https://link.springer.com/article/10.1007/s41061-017-0112-0
Feb 08, 2017 · Abstract. As an option for genetic disease treatment and an alternative for traditional cancer chemotherapy, gene therapy achieves significant attention. Nucleic acid delivery, however, remains a main challenge in human gene therapy. Polymer-based delivery systems offer a safer and promising route for therapeutic gene delivery.Author: Peng Zhang, Peng Zhang, Ernst Wagner, Ernst Wagner
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277219/
Nov 22, 2011 · Two rounds of evolution were performed, with clonal analysis (cap gene sequencing and hESC gene delivery assay for each selected virus) performed between each round of evolution. Following the third selection step, AAV cap genes were isolated from the pool of successful AAV variants and amplified via PCR.Author: Prashanth Asuri, Prashanth Asuri, Melissa A Bartel, Melissa A Bartel, Tandis Vazin, Tandis Vazin, Ja...
https://www.sciencedirect.com/science/article/pii/S0168365911006742
Disulfide-containing cross-linked PEI derivative synthesized by click chemistry for non-viral gene delivery Author links open overlay panel Jia Liu 1 Li Xu 1 Xulin Jiang 1 Wim E. Hennink 2 …Author: Jia Liu, Li Xu, Xulin Jiang, Wim E. Hennink, Xianmiao Wang, Renxi Zhuo
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