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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425417/
Nov 07, 2014 · 2. Typical enzymes for controlled drug delivery. In this section, several typical classes of enzymes that serve as the triggers in enzyme-responsive controlled drug delivery are discussed. As summarized in Fig. 1, drugs can be triggered to release through a variety of enzymatic implementations.Author: Quanyin Hu, Prateek S. Katti, Zhen Gu
https://pubs.rsc.org/en/content/articlelanding/2014/nr/c4nr04249b
Exploiting altered enzyme activity and expression for diagnostics, drug targeting, and drug release is tremendously promising. When combined with booming research in nanobiotechnology, enzyme-responsive nanomaterials used for controlled drug release have achieved significant development and have been studied as an important class of drug delivery strategies in nanomedicine.Author: Quanyin Hu, Prateek S. Katti, Zhen Gu
https://www.sciencedirect.com/science/article/pii/S0168365919303918
In another study, a biocompatible matrix metalloproteinase-responsive drug delivery system based on mesoporous silica nanoparticles was fabricated for targeted delivery of doxorubicin hydrochloride …Author: Mahsa Shahriari, Mahsa Zahiri, Khalil Abnous, Seyed Mohammad Taghdisi, Mohammad Ramezani, Mona Alibo...
https://www.sciencedirect.com/science/article/pii/B9780081019979000047
To achieve clinically translatable enzyme-responsive drug delivery systems, several factors should be considered: (1) physicochemical properties (e.g., molecular weight, degree of polymerization, hydrophobicity, surface charge), intra-/intermolecular forces, biocompatibility, biodegradation kinetics, and toxicity; (2) The incorporated bio-recognition moieties or enzyme substrates can be easily and …Author: Junqing Wang, Huaping Zhang, Fang Wang, Xixi Ai, Dan Huang, Gang Liu, Peng Mi
https://onlinelibrary.wiley.com/doi/full/10.1002/advs.201802315
Therefore, the substrate lignin was chosen as a carrier material, to develop an enzyme‐responsive drug delivery system. Since the disease‐associated fungi degrade the loaded lignin NCs, the fungicide is released exclusively in the case of infection, which allows not only a curative treatment but also long‐term protection (Scheme 1).Author: Jochen Fischer, Sebastian J. Beckers, Doungporn Yiamsawas, Eckhard Thines, Eckhard Thines, Katharina...
http://www.eurekaselect.com/132432/article
An emerging field in anticancer drug delivery is to design enzyme-responsive nanoparticles, which may enable efficient accumulation in tumor tissues via the EPR effect and on demand release of the drug in response to enzymes. Many strategies were proposed to promote the development of efficient enzyme-responsive nanoparticles.Author: Tairong Kuang, Yarong Liu, Tiantian Gong, Xiangfang Peng, Xianglong Hu, Zhiqiang Yu
http://www.thno.org/v10p4557.htm
Enzymes play an important role in biological reactions, while the unregulated expression of certain enzymes in neoplastic conditions could be triggers for enzyme-responsive drug delivery. Several enzyme- responsive nanocarriers have been engineered for achieving controlled release of cargos in tumors and cancer cells [280, 281], prodrug/ligands activation, as well as morphology change, mainly …
https://pubs.rsc.org/en/content/articlepdf/2017/sc/c7sc00472a
enzyme-responsive drug delivery system for the efficient therapy of breast and pancreatic cancers† Brigitte Renoux,‡a Florian Raes,‡b Thibaut Legigan,a Elodie Peraudeau,´ cd Balkis Eddhif,e Pauline Poinot,e Isabelle Tranoy-Opalinski,a Jer´ ome Alsarraf,ˆ a Oleksandr Koniev,f Sergii Kolodych,f Stephanie Lerondel,´ b Alain Le Pape,bAuthor: Brigitte Renoux, Florian Raes, Thibaut Legigan, Elodie Péraudeau, Balkis Eddhif, Pauline Poinot, Isa...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509414/
Apr 19, 2017 · Liposomal prodrugs are also of considerable interest for enzyme responsive delivery. In this approach, liposomes contain drug molecules chemically conjugated to the lipids of the bilayer. The active drug is released from liposomes after the linker is cleaved by an enzyme in the target site.Author: Farnaz Fouladi, Kristine J. Steffen, Sanku Mallik
https://pubs.acs.org/doi/abs/10.1021/acsbiomaterials.8b00327
The in vivo antitumor test demonstrated the excellent efficiency of our system for tumor targeting drug delivery and tumor growth inhibition. Therefore, this dual enzyme-responsive drug delivery system provided an efficient platform for cancer therapy.Author: Juan Zhou, Mingyu Wang, Huiyan Ying, Dandan Su, Huijie Zhang, Guozhong Lu, Jinghua Chen
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