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https://www.sciencedirect.com/science/article/pii/S0302459899000264
This report describes the first feasibility study of electroporation-mediated topical delivery (EMTD) of Asc for potential cosmetic applications. Both a cream formulation (20% Asc) and a crystal suspension (33% Asc) were applied respectively to human cadaver skin and fresh surgical skin.Author: Lei Zhang, Sheldon Lerner, William V Rustrum, Günter A Hofmann
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756005/
Topical gene delivery to the epidermis has the potential to be an effective therapy for skin disorders, cutaneous cancers, vaccinations and systemic metabolic diseases. Previously, we reported on a non-invasive multielectrode array (MEA) that efficiently delivered plasmid DNA and enhanced expression to the skin of several animal models by in vivo gene electrotransfer.Author: Siqi Guo, Annelise L. Israel, Gaurav Basu, Amy Donate, Richard Heller
https://www.nibib.nih.gov/news-events/newsroom/story-discovery-painless-drug-delivery
Studies also suggest that electroporation could be used to deliver compounds that would ameliorate skin aging, such as particular genes or Vitamin C. NIH-supported scientists have found that transdermal drug delivery via electroporation can be enhanced through the use of mild heat, alkaline solutions, and sodium dodecyl sulfate (a detergent used in various household products, including toothpaste, shampoo…
https://www.researchgate.net/publication/237061438_Vitamin_C_in_dermatology
Vitamin C is a potent antioxidant drug that can be used topically in dermatology to treat and prevent changes associated with photoageing. It can also be used for the treatment of hyperpigmentation.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673383/
ADVERSE REACTIONS OF TOPICAL VITAMIN C. Topical Vit. C is largely safe to use on a daily basis for long durations. It can safely be used in conjunction with other common topical anti-ageing agents such as sunscreens, tretinoin, other antioxidants and alfa hydroxy acids such as glycolic acid.
https://www.cellularskinrx.com/putting-l-ascorbic-acid-vitamin-c-in-a-water-or-cream-base-degrades-the-l-ascorbic-acid/
Ascorbic acid is a water-soluble vitamin and is extensively used as such or in the form of a derivative such as sodium ascorbate and ascorbyl palmitate as an ingredient of anti-aging cosmetic products. It exerts several functions on the skin such as collagen synthesis, depigmentation and antioxidant activity.
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