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https://www.sciencedirect.com/science/article/pii/S0169409X03001923
Incorporation of sensing components into MEMS can allow delivery of drugs to be attuned to changes in the physiological environment surrounding the device, similar to polymeric delivery systems that can be triggered by a change in the local environment such as the application of ultrasound , , changes in pH , , , temperature , , analyte concentrations , , and electric , , or magnetic , fields. The small size of MEMS …Author: Amy C. Richards Grayson, Rebecca Scheidt Shawgo, Yawen Li, Michael J. Cima
http://www.uta.edu/rfmems/Telemetry/Implant%20Sensor/29543_Electronic%20MEMS%20for%20triggered%20delivery.pdf
The usage of MEMS for triggered, particularly pulsatile, delivery of drugs and other substances in vivo represents a new area of study that is only now beginning to be explored. The digital capabilities of MEMS may allow greater temporal control over drug release compared to traditional polymer-based systems, while the batch-processing techniques used
https://www.ncbi.nlm.nih.gov/pubmed/14741114
Feb 10, 2004 · The usage of microfabrication techniques to produce microelectromechanical systems (MEMS) has allowed engineers to address a wider range of clinical indications. A new direction in the area of MEMS technology is the goal of achieving pulsatile drug delivery.Author: Amy C. Richards Grayson, Rebecca Scheidt Shawgo, Yawen Li, Michael J. Cima
https://www.academia.edu/13462626/Electronic_MEMS_for_triggered_delivery
Electronic MEMS for triggered delivery
https://link.springer.com/chapter/10.1007%2F978-3-540-68017-8_80
This paper overviews various components of MEMS drug delivery devices in medical application such as micropumps, microvalves, microactuator and microneedles, using biocompatible material such as silicon. The review will focus on micropumps structures in different actuators.Author: S. Karman, F. Ibrahim, N. Soin
https://www.sciencedirect.com/science/article/pii/S0924424711003633
A novel electronic capsule for drug delivery in alimentary canal at a desired time point has been designed, fabricated and tested. This electronic capsule consists of four components: timer module, driving unit, power supply, and a microfluidic chamber for drug reservoir.Author: Yinping Zhuang, Yinping Zhuang, Wensheng Hou, Xiaolin Zheng, Zhigang Wang, Jun Zheng, Xitian Pi, Jia...
https://link.springer.com/article/10.1007%2Fs11095-006-9906-4
May 05, 2006 · Micro- and nano-electromechanical systems (MEMS and NEMS)-based drug delivery devices have become commercially-feasible due to converging technologies and regulatory accommodation. The FDA Office of Combination Products coordinates review of innovative medical therapies that join elements from multiple established categories: drugs, devices, and biologics. …Author: Mark Staples, Karen Daniel, Michael J. Cima, Robert Langer
https://www.youtube.com/watch?v=hPKlC5tEarI
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