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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3574231/
Feb 15, 2013 · Short peptide motifs such as FΦR 4 provide useful and likely general transporters for intracellular delivery of cyclic peptides. If a target-binding cyclic peptide is already available, one may simply replace the residues noncritical for target binding with FΦR 4. The designed cyclic peptides should have ring sizes of 7 to 13 amino acids; larger rings will likely have poor cellular uptake activities, whereas cyclic peptides …Author: Ziqing Qian, Tao Liu, Yu Yu Liu, Roger Briesewitz, Amy M. Barrios, Sissy M. Jhiang, Dehua Pei
https://pubs.acs.org/doi/full/10.1021/cb3005275
Early Endosomal Escape of a Cyclic Cell-Penetrating Peptide Allows Effective Cytosolic Cargo Delivery. Biochemistry 2014 , 53 (24) , 4034-4046. DOI: 10.1021/bi5004102.Author: Ziqing Qian, Tao Liu, Yu Yu Liu, Roger Briesewitz, Amy M. Barrios, Sissy M. Jhiang, Dehua Pei
https://pubs.acs.org/doi/abs/10.1021/cb3005275
Here, we report a potentially general approach for intracellular delivery of cyclic peptides. Short peptide motifs rich in arginine and hydrophobic residues (e.g., FφRRRR, where φ is l -2-naphthylalanine), when embedded into small- to medium-sized cyclic peptides (7–13 amino acids), bound to the plasma membrane of mammalian cultured cells...Author: Ziqing Qian, Tao Liu, Yu Yu Liu, Roger Briesewitz, Amy M. Barrios, Sissy M. Jhiang, Dehua Pei
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653137/
May 06, 2013 · In summary, a new carrier system for the delivery of cell impermeable phosphopeptides was discovered using cyclic octapeptide [WR] 4 containing alternative tryptophan and arginine residues. The cellular uptake of F′-PEpYLGLD was enhanced by 27-fold in the presence of [WR] 4 , and was found to be time-dependent.Author: Amir Nasrolahi Shirazi, Rakesh Kumar Tiwari, Donghoon Oh, Antara Banerjee, Arpita Yadav, Keykavous P...
https://pubs.acs.org/doi/10.1021/mp400046u
Efficient Delivery of Cell Impermeable Phosphopeptides by a Cyclic Peptide Amphiphile Containing Tryptophan and Arginine Molecular Pharmaceutics Phosphopeptides are valuable reagent probes for studying protein–protein and protein–ligand interactions.Author: Amir Nasrolahi Shirazi, Rakesh Kumar Tiwari, Donghoon Oh, Antara Banerjee, Arpita Yadav, Keykavous P...
https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.9b00633
Cyclic cell-penetrating peptides are relatively a newer class of peptides that have a huge potential for the intracellular delivery of therapeutic agents aimed at treating challenging ailments like multidrug-resistant bacterial diseases, cancer, and HIV infection. Cell-penetrating peptides (CPPs) have been extensively explored as intracellular delivery vehicles; however, they have some ...Author: Shang Eun Park, Muhammad Imran Sajid, Muhammad Imran Sajid, Keykavous Parang, Rakesh Kumar Tiwari
https://www.researchgate.net/publication/232959469_Efficient_Delivery_of_Cyclic_Peptides_into_Mammalian_Cells_with_Short_Sequence_Motifs
Request PDF Efficient Delivery of Cyclic Peptides into Mammalian Cells with Short Sequence Motifs Cyclic peptides hold great potential as therapeutic agents and research tools, but their broad ...
https://www.ncbi.nlm.nih.gov/pubmed/27089101
May 10, 2016 · In this study, a family of small, amphipathic cyclic peptides was found to be highly efficient CPPs, with cytosolic delivery efficiencies of up to 120% (compared to 2.0% for Tat). These cyclic CPPs bind directly to the plasma membrane phospholipids and enter mammalian cells via endocytosis, followed by efficient release from the endosome.Author: Ziqing Qian, Agnieszka Martyna, Ryan L. Hard, Jiang Wang, George Appiah-Kubi, Christopher Coss, Mitc...
https://pubs.acs.org/doi/abs/10.1021/acs.biochem.6b00226
In this study, a family of small, amphipathic cyclic peptides was found to be highly efficient CPPs, with cytosolic delivery efficiencies of up to 120% (compared to 2.0% for Tat ). These cyclic CPPs bind directly to the plasma membrane phospholipids and enter mammalian cells via endocytosis, followed by efficient release from the endosome.Author: Ziqing Qian, Agnieszka Martyna, Ryan L. Hard, Jiang Wang, George Appiah-Kubi, Christopher Coss, Mitc...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075989/
Jun 24, 2014 · In recent years, there has been much interest in cyclic peptides as therapeutic agents and biomedical research tools. 69,70 For example, cyclic peptides are effective for inhibition of protein–protein interactions, 47,71−73 which are challenging targets for conventional small molecules.Author: Ziqing Qian, Jonathan R. LaRochelle, Bisheng Jiang, Wenlong Lian, Ryan L. Hard, Nicholas G. Selner, ...
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