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https://www.sciencedirect.com/science/article/pii/S2211383513000178
For many years, drug delivery to the inner ear has been a challenge to physicians in the treatment of inner ear disorders. In the past decade, the field of inner ear drug delivery has emerged with the development of new biomaterials and drug delivery technologies to improve the effectiveness of …Author: Hongzhuo Liu, Hongzhuo Liu, Jinsong Hao, Kevin S. Li
https://www.ncbi.nlm.nih.gov/pubmed/23323784
Drug delivery to the ear is used to treat conditions of the middle and inner ear such as acute and chronic otitis media, Ménière's disease, sensorineural hearing loss and tinnitus. Drugs used include antibiotics, antifungals, steroids, local anesthetics and neuroprotective agents.Author: E Hoskison, M Daniel, S Al-Zahid, KM Shakesheff, R Bayston, JP Birchall
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836414/
Emerging microfluidics and microsystems technologies have been used toward the development of a reciprocating inner ear drug delivery system by engineers and researchers at the Charles Stark Draper Laboratory (Cambridge, MA) and Massachusetts Eye and Ear Infirmary and applied to the cochlea in a guinea pig model (Chen et al. 2005, Sewell et al ...Author: Andrew A. McCall, Erin E. Leary Swan, Jeffrey T. Borenstein, William F. Sewell, Sharon G. Kujawa, Mi...
https://journals.lww.com/thehearingjournal/Fulltext/2019/07000/Inner_Ear_Drug_Delivery__Tomorrow_s_Treatment_for.1.aspx
In tandem with drug formulation, a highly influential factor impacts the progress in ushering inner ear therapies to the market: the drug delivery system specifically, determining the appropriate delivery system that will most safely and effectively transport the medication in the desired manner, while also prioritizing patient comfort.
https://www.sciencedirect.com/science/article/pii/S0169409X16300060
This finding highlights the importance of a sustained drug delivery system that can maintain therapeutic doses of drug within the inner ear. Moreover, the persistence of the base-apex concentration gradient generates a need for targeted inner ear delivery such that a drug may preferentially bind to apical cells without affecting basilar cells.Author: Lilun Li, Lilun Li, Tiffany Chao, Jason Brant, Bert O'Malley, Andrew Tsourkas, Daqing Li
https://www.draper.com/news-releases/novel-drug-delivery-device-inner-ear-disorders-heads-preclinical-test-prompts
Nov 06, 2017 · “For diseases of the inner ear, clinical research and treatment have been held back by the need for a safe, direct and effective intracochlear drug delivery method. We address this challenge with Draper’s device—the first implantable and programmable micropump that provides targeted, controllable and extended drug delivery.
https://spectrum.ieee.org/biomedical/devices/flexible-microsystems-deliver-drugs-through-the-ear
Any drug-delivery system for the ear will require extremely high-precision engineering to navigate the intricate internal geometry of the cochlea. This structure contains a coiled, snail-like tube ...
https://www.slideshare.net/farzana777/advanced-drug-delivery-systems
May 17, 2016 · The term “drug delivery systems” refers to the technology utilized to present the drug to the desired body site for drug release and absorption. The first drug delivery system developed was the syringe, invented in 1855, used to deliver medicine by injection. The modern transdermal patch is an example of advanced drug delivery system.
https://www.researchgate.net/publication/324565100_Otic_Drug_Delivery_Systems_Formulation_Principles_and_Recent_Developments
Otic drug delivery technology will likely evolve in the next decade and more efficient or specific treatments for ear disease will arise from the development of less invasive drug delivery methods ...
https://www.scintica.com/new-journal-article-ultrasound-induced-microbubble-cavitation-via-a-transcanal-or-transcranial-approach-facilitates-inner-ear-drug-delivery/
Unfortunately, the RWM is only semi-permeable thereby limiting the passage of drugs into the inner ear. As such, many methods are currently being developed to increase the permeability of this membrane, and thus the efficiency of the drug delivery system. Ultrasound-induced Microbubble Cavitation (USMB) is one such method.
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