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https://www.jstage.jst.go.jp/article/kona/20/0/20_2002010/_pdf
Dry Powders for Pulmonary Delivery of Peptides and Proteins † Abstract Because proteins and peptides are poorly absorbed through the gastrointestinal tract, the lungs are a promising organ for administering these substances because of their large inner surface area, thin epithelium, and relatively low protease activity.Author: Hirokazu Okamoto, Hiroaki Todo, Kotaro Iida, Kazumi Danjo
https://www.sciencedirect.com/science/article/pii/B9780123849359100021
Proteins and peptides can be delivered using a variety of aerosol devices such as nebulizers, the AERx ® pulmonary delivery system, metered dose inhalers, and dry powder inhalers. This chapter provides an overview of the clinical and formulation aspects of inhalation delivery of proteins and peptides.Author: Philip Chi Lip Kwok, Hak-Kim Chan
https://www.researchgate.net/publication/274241546_Dry_Powders_for_Pulmonary_Delivery_of_Peptides_and_Proteins
Request PDF Dry Powders for Pulmonary Delivery of Peptides and Proteins Because proteins and peptides are poorly absorbed through the gastrointestinal tract, the lungs are a promising organ ...
https://www.ncbi.nlm.nih.gov/pubmed/16296721
The pulmonary route is an interesting route for drug administration, both for effective local therapy (asthma, chronic obstructive pulmonary disease or cystic fibrosis) and for the systemic administration of drugs (e.g., peptides and proteins). Well-designed dry powder inhalers are highly efficient systems for pulmonary drug delivery.Author: H.W. Frijlink, A.H. De Boer
https://link.springer.com/article/10.1208/pt060480
Dec 01, 2005 · Liposomal dry powders as aerosols for pulmonary delivery of proteins. Abstract. The purpose of this research was to develop liposomal dry powder aerosols for protein delivery. The delivery of stable protein formulations is essential for protein subunit vaccine delivery, which requires local delivery to macrophages in the lungs.Author: Dongmei Lu, Anthony J. Hickey
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948054/
Robust gene delivery is afforded by pH responsive peptides in the presence of BALF used to model the affect of airway surface liquid. Inhalable, pH responsive, peptide-based, plasmid DNA dry powder formulations can be successfully produced by spray drying …Author: Wanling Liang, Philip C.L. Kwok, Philip C.L. Kwok, Michael Y.T. Chow, Patricia Tang, A. James Mason,...
https://www.sciencedirect.com/science/article/pii/S0168365919305917
In particular, dry powder formulation is highly desirable for pulmonary delivery. While liquid aerosol can be delivered to the lungs of patients through nebulization, dry powder formulation of nucleic acids offers several additional advantages such as superior stability, better sterility and longer shelf-life . Dry powder inhalers are also cheaper and easier to operate than nebulizers.Author: Yingshan Qiu, Rico C.H. Man, Qiuying Liao, Keshia L.K. Kung, Michael Y.T. Chow, Michael Y.T. Chow, J...
https://www.ondrugdelivery.com/overview-dry-powder-inhalation-systemic-drug-delivery/
The use of the pulmonary route for delivering proteins and peptides is a viable proposition, the challenges and perspectives being discussed in a review paper in 2013. 14 Three available delivery devices were analysed: nebulisers, MDIs and DPIs, with the fact that only DPIs did not use liquid formulations being highlighted. The particle size ...
https://www.ondrugdelivery.com/pulmonary-delivery-antimicrobial-peptides/
The most studied peptide for pulmonary delivery is insulin, for which rapid systemic delivery is the target. Such a product was on the market for a short period in 2006/2007. For improved delivery and to avoid phagocytosis insulin was spray-dried as larger very porous particles (Pulmospheres ® ).
https://www.researchgate.net/publication/232051208_Dry_powder_inhalation_systems_for_pulmonary_delivery_of_therapeutic_peptides_and_proteins
Background: Dry powder inhaler (DPI) systems are widely accepted as an alternative to injection and oral administration of therapeutic peptides and proteins. In contrast to oral therapy, pulmonary administration eliminates the potential for poor absorption...
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