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https://www.sciencedirect.com/science/article/pii/S1461534798000996
This review examines the key issues surrounding the development and preparation of formulations for dry powder inhalers. The various inhaler devices that are currently available for achieving pulmonary drug deposition, from both liquid and dry powder formulations, are discussed and pulmonary physiology, as it relates to drug delivery via the lung, is briefly reviewed.Author: Richard J Malcolmson, Jonathan K Embleton
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3146747/
Sep 01, 2010 · Despite the fact that the breathing pattern for liquid delivery (tidal breathing), and dry powder delivery (forceful inhalation) differ significantly, the relative distribution of tobramycin within the central, intermediate, and peripheral airways is similar for both formulations, with a trend for greater deposition in the peripheral versus ...Author: David E. Geller, Jeffry Weers, Silvia Heuerding
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1884297/
Apr 18, 2002 · Pulmonary delivery devices. The lung has served as a route of drug administration for thousands of years. The origin of inhaled therapies can be traced back 4000 years ago to India, where people smoked the leaves of the Atropa belladonna plant to suppress cough. In the 19th and early 20th centuries, asthmatics smoked asthma cigarettes that contained stramonium powder mixed with …Author: N. R. Labiris, M. B. Dolovich
https://www.ondrugdelivery.com/overview-dry-powder-inhalation-systemic-drug-delivery/
By this point, devices for delivery via the pulmonary route had already been developed: nebulisers, metered dose inhalers (MDIs) and dry powder inhalers (DPIs). 3,4 The former two use various solvents, both aqueous and organic, thus meaning DPIs offer the best prospect for developing a stable system. Devices for inhalation therapy must be able ...
https://link.springer.com/article/10.1007/s11095-018-2452-z
Aug 23, 2018 · Pulmonary delivery of biologics is of great interest, as it can be used for the local treatment of respiratory diseases or as a route to systemic drug delivery. To reach the full potential of inhaled biologics, a formulation platform capable of producing high performance aerosols without altering protein native structure is required. A formulation strategy using Particle Replication in Non ...Author: Erin M. Wilson, J. Christopher Luft, Joseph M. DeSimone, Joseph M. DeSimone
https://www.sciencedirect.com/science/article/pii/S0168365919305917
PEG 12 KL4 peptide is a promising mRNA delivery vector for pulmonary delivery.. Inhalable mRNA dry powder can be prepared by spray drying and spray freeze drying. • PEG 12 KL4/mRNA formulations did not cause significant toxicity and inflammatory response.Author: Yingshan Qiu, Rico C.H. Man, Qiuying Liao, Keshia L.K. Kung, Michael Y.T. Chow, Michael Y.T. Chow, J...
https://www.assignmentpoint.com/science/pharmacy/dry-powder-formulation-for-pulmonary-delivery.html
Pulmonary delivery of therapeutic peptides via dry powder inhalation– General Introduction : Preparing dry powder formulations for inhalation is an attractive and appreciated proposition because many solubility and stability issues can be avoided [7,8].
https://www.cell.com/trends/biotechnology/fulltext/S0167-7799(10)00221-0
Apr 01, 2011 · This review describes our current understanding of pulmonary immunization, including possible barriers facing the development of pulmonary vaccines, and discusses recent advances in spray-drying technologies applicable to the production of …Author: Tomas Sou, Elza Meeusen, Michael John de Veer, David Morton, Lisa Kaminskas, Michelle Paula McIntosh
https://www.researchgate.net/publication/49775189_New_development_in_dry_powder_pulmonary_vaccine_delivery
New development in dry powder pulmonary vaccine delivery ... and discusses recent advances in spray-drying technologies applicable to the production of dry powder formulations for pulmonary ...
https://www.hindawi.com/journals/jdd/2018/5635010/
Various investigations on dry powder coating formulations of inhaled lactose are portrayed in Table 10. ... a focus on advancements in novel drug delivery systems,” Journal of Drug Delivery, vol. 2016, pp. 1–17 ... “Freeze-dried mannitol for superior pulmonary drug delivery via dry powder inhaler,” Pharmaceutical Research, vol. 30 ...Author: Piyush Mehta
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