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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161002/
Aug 21, 2018 · Budesonide, a poorly water-soluble corticosteroid anti-inflammatory drug, was formulated as nanocrystals loaded into hyaluronic acid microparticles. Budesonide nanocrystals exhibited prolonged retention on the surface porcine tracheal tube thanks to the mucoadhesive properties of hyaluronic acid, which significantly improved the drug bioavailability [ 14 ].Author: Maria Rosa Gigliobianco, Cristina Casadidio, Roberta Censi, Piera Di Martino
https://www.sciencedirect.com/science/article/pii/S0939641105001797
A meanwhile classical formulation approach for such poorly soluble drugs is micronisation, that means transfer of the coarse drug powder to an ultrafine powder with a mean particle size being typically in the range of 2–5 μm, size distributions normally range from approximately 0.1 to 25 μm , . It should be pointed out that only a negligible fraction of the population is below 1 μm.Author: Cornelia M. Keck, Rainer H. Müller
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217698/
Nanosuspensions consist of the poorly water-soluble drug without any matrix material suspended in dispersion. These can be used to enhance the solubility of drugs that are poorly soluble in water as well as lipid media.
https://www.worldscientific.com/doi/abs/10.1142/9781860949074_0014
Physicochemical Properties of Drug Nanocrystals . Change of dissolution velocity. Saturation solubility. Does size really matter? Effect of amorphous particle state. Production Methods . Precipitation methods. Homogenization methods. Combination Technologies. Application Routes and Final Formulations . Oral administration. Parenteral administration
https://www.sciencedirect.com/science/article/pii/S135902861200054X
Nanocrystals are used in dermal applications to enhance the dissolution of poorly soluble drugs in aqueous phase, thereby increasing the concentration gradient between the formulation and the skin and, thereby, transdermal penetration of the drug .Author: Bo Sun, Yoon Yeo, Yoon Yeo
https://www.researchgate.net/publication/285685058_Drug_nanocrystals_A_novel_formulation_approach_for_poorly_soluble_drugs
Preparation of drug nanocrystals to improve the solubility of poorly water-soluble drugs for oral delivery is also one of the important applications. Nanocrystal dispersions comprise water, active ...
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