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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409749/
Feb 17, 2019 · Nose-to-brain drug delivery is a painless, non-invasive administration route that can be used to deliver therapeutic agents into the brain by bypassing the BBB [10,14,15,16,17]. These drug administration pathways are characterized by many advantages such as increased patient compliance, high safety, remarkable ease of administration and rapid onset of action, as well as minimized …Author: Maria Cristina Bonferoni, Silvia Rossi, Giuseppina Sandri, Franca Ferrari, Elisabetta Gavini, Giovan...
http://www.iptonline.com/articles/public/IPTTEN90NoPrint.pdf
drug delivery via the nasal route can also apply at the local level —which is some-times overlooked Drug delivery via the nose As more therapeutic peptides and proteins are developed, nasal drug delivery offers an ever more viable alternative to the oral and injectable routes. Melissa Koch, West Pharmaceutical Services Inc DRUG DELIVERY & FORMULATION
https://drug-dev.com/nasal-delivery-a-promising-route-of-drug-delivery-to-the-brain-scientific-considerations-2/
The nasal route of drug delivery is one such alternate route that provides access to highly vascularized mucosa, which can be exploited as an interesting site for local drug delivery, systemic drug delivery, and targeted drug delivery (CNS).
http://jpet.aspetjournals.org/content/370/3/593
Sep 01, 2019 · The delivery of biologics via the nose-to-brain route is an area where the route is theoretically able to really offer the most impact. Solid evidence for the delivery of biologics exceeding a mol. wt. of 10 kDa to the brain is relatively rare.Author: Zian Wang, Guojun Xiong, Wai Chun Tsang, Andreas G. Schätzlein, Ijeoma F. Uchegbu
https://www.pharmatutor.org/articles/nanosuspension-novel-drug-delivery-system-via-nose-brain-drug-delivery
Nanosuspension drug delivery via the nose to brain is considered to be a promising route. This route is a useful when rapid onset of action is desired with better patient compliance than the other formulations. In terms of permeability, this route is more permeable than the other routes, which in turn is more permeable than the other route.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161189/
Aug 03, 2018 · In contrast, nose-to-brain delivery is a minimally invasive drug administration pathway, which bypasses the blood-brain barrier as the drug is directed from the nasal cavity to the brain. In particular, the skull base located at the roof of the nasal cavity is in close vicinity to the CNS.Author: Stella Gänger, Katharina Schindowski
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539067/
Oct 18, 2012 · Nasal anatomy and physiology influencing drug delivery. Regulation of nasal airflow. Nasal breathing is vital for most animals and also for human neonates in the first weeks of life. The nose is the normal and preferred airway during sleep, rest, and mild exercise up …Author: Per Gisle Djupesland
https://www.slideshare.net/ishanipandit034/brain-targeted-drug-delivery-through-nasal-route
Mar 01, 2015 · INTRODUCTION Drug delivery through nasal route has been potentially explored as an alternative route for the administration of vaccines and biomolecules such as proteins, peptides and non-peptide drugs that are susceptible to enzymatic or acidic degradation and first-pass hepatic metabolism. The nasal mucosa is one of the most permeable and highly vascularized site for drug administration …
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