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https://link.springer.com/article/10.1007/s11910-001-0020-z
May 01, 2001 · Contemporary treatment of malignant brain tumors has been hampered by problems with drug delivery to the tumor bed. Inherent boundaries of the central nervous system, such as the blood-brain barrier or the bloodcerebrospinal fluid barrier, and a general lack of response to many chemotherapeutic agents have led to alternative treatment modalities.Author: Maciej S. Lesniak, Robert Langer, Henry Brem
https://www.sciencedirect.com/science/article/pii/B9780128139974000219
Drugs can be delivered to the central nervous system via several different approaches, the most common of which are systemic delivery and direct injection/implantation into the tumor or surrounding brain.Author: Lee S. Hwang, Daria Krivosheya, Michael A. Vogelbaum
https://www.scholars.northwestern.edu/en/publications/drug-delivery-to-tumors-of-the-central-nervous-system
Contemporary treatment of malignant brain tumors has been hampered by problems with drug delivery to the tumor bed. Inherent boundaries of the central nervous system, such as the blood-brain barrier or the blood-cerebrospinal fluid barrier, and a general lack of response to many chemotherapeutic agents have led to alternative treatment modalities.Author: Maciej S. Lesniak, Robert Langer, Henry Brem
https://www.sciencedirect.com/science/article/pii/S0169409X12000075
May 15, 2012 · Convection-enhanced delivery (CED) is a type of direct administration that uses positive pressure to increase circulation of drug throughout the tumor, and to reduce the influence of therapeutic molecular weight on distribution.Author: Laura P. Serwer, C. David James
https://www.researchgate.net/publication/11464402_Drug_delivery_to_tumors_of_the_central_nervous_system
Fluorescent nanoparticles were mainly distributed to liver and spleen of mice. Paclitaxel-loaded PLGA nanoparticles may be considered a promising drug delivery system to eradicate hypoxic tumor...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792490/
Treating central nervous system diseases is very challenging because of the presence of a variety of formidable obstacles that impede drug delivery. Physiological barriers like the blood-brain barrier and blood-cerebrospinal fluid barrier as well as various efflux transporter proteins make the entry of drugs into the central nervous system very ...
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