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https://www.sciencedirect.com/science/article/pii/S1359644618305117
The photoreceptors of the retina are afflicted by diseases that still often lack satisfactory treatment options. Although suitable drugs might be available in some cases, the delivery of these compounds into the eye and across the blood–retinal barrier remains a significant challenge for therapy development.Author: Erico Himawan, Per Ekström, Matej Buzgo, Pieter Gaillard, Einar Stefánsson, Valeria Marigo, Thorstei...
https://www.sciencedirect.com/science/article/pii/S1350946216300635
As the mechanisms of retinal diseases are investigated and revealed, new potential drug targets will emerge. The delivery of drugs to retinal targets is challenging and various routes of drug administration have been investigated ().Unfortunately, most of them result in sub-therapeutic drug levels in the retina.Author: Eva M. del Amo, Anna-Kaisa Irmeli Rimpelä, Emma Heikkinen, Otto K. Kari, Eva Ramsay, Tatu Lajunen, M...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010371/
Jun 18, 2018 · Drug delivery strategies targeting the retina range from systemic administration to the clinically commonly used intravitreal injections. Representative examples of retinal drug delivery systems under research are listed in Table 1.Author: Sibo Jiang, Yesenia L Franco, Yan Zhou, Jianjun Chen
https://www.retinalphysician.com/issues/2020/march-2020/the-retinal-drug-delivery-pipeline
Mar 01, 2020 · There are new treatments coming down the pipeline, including the Port Delivery System (PDS; Genentech), sustained-delivery compounds, and gene therapies. In this roundtable discussion, Allen Ho, MD, leads a conversation about pipeline therapies related to retinal drug delivery.Author: Robert L. Avery, MD
https://www.ondrugdelivery.com/zero-order-sustained-drug-delivery-retina-nanoporous-film-device/
A proportion does reach the retina but during the two or three weeks following injection, the drug is present at the target tissue in steadily declining amounts. Zordera’s core technology is a nano-engineered device that allows transport of drug molecules from a reservoir through a nanometre-sized porous biodegradable polymer thin-film.
https://www.ncbi.nlm.nih.gov/pubmed/28425224
Effective drug delivery to the retina still remains a challenge due to ocular elimination mechanisms and complex barriers that selectively limit the entry of drugs into the eye. To overcome these barriers, frequent intravitreal injections are currently used to achieve high drug concentrations in vitreous and retina.Author: Rohit Bisht, Abhirup Mandal, Jagdish K. Jaiswal, Ilva D. Rupenthal
https://www.amazon.com/Delivery-Retina-Posterior-Segment-Disease-ebook/dp/B07J9X5S8F
A rapid expansion of new technologies in ocular drug delivery and new drug candidates, including biologics, to treat these challenging diseases in the retina and posterior segments of the eye have recently emerged. These approaches are necessary because …Manufacturer: Springer
https://cme.healio.com/ophthalmology/20191001/drug-delivery-in-neovascular-retinal-disease/overview?login=1
Drug Delivery in Neovascular Retinal Disease. This activity is supported by an educational grant from Genentech, Inc.
http://retinatoday.com/pdfs/0916RT_Mini_Olsen.pdf
50 RETINA TODAY SEPTEMBER 2016 PECAL FC DRUG DELIVERY Questions, thoughts, and opinions related to current and emerging drug delivery systems. BY TIMOTHY W. OLSEN, MD DRUG DELIVERY TO THE RETINA Drug delivery systems that target retinal diseases continue to evolve. Improvements may appear to be slow in evolving, yet the
https://www.liebertpub.com/doi/10.1089/jop.2012.0128
Up to this date, several delivery systems have been designed to deliver drugs to the retina. Drug delivery strategies may be classified into 3 groups: noninvasive techniques, implants, and colloidal carriers. The best known systems for drug delivery to the posterior eye are intravitreal implants; in fact, some of them are being clinically used.Author: Ana del Pozo-Rodríguez, Diego Delgado, Alicia R. Gascón, Maria Ángeles Solinís
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