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https://www.slideshare.net/VARSHAAWASAR/brain-targeted-drug-delivery-system
Aug 04, 2014 · INTRODUCTION • Drug delivery to the brain is the process of passing therapeutically active molecules across the Blood Brain Barrier for the purpose of treating brain maladies.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998643/
Many approaches to overcome, circumvent, disrupt, or manipulate the BBB to enhance delivery of drugs to brain tumors have been devised and are in active investi gation. These approaches include high-dose intravenous chemotherapy, intra-arterial drug delivery, local drug delivery via implanted polymers or catheters, BBB dis ruption, and biochemical modulation of drugs.Author: Jaishri Blakeley
https://www.elsevier.com/books/brain-targeted-drug-delivery-systems/gao/978-0-12-814001-7
Brain Targeted Drug Delivery Systems: A Focus on Nanotechnology and Nanoparticulates provides a guide on nanoparticulates to both academic and industry researchers. The book discusses key points in the development of brain targeted drug delivery, summarizes available strategies, and considers the main problems and pitfalls evidenced in current studies on brain targeted drug delivery systems.
https://www.slideshare.net/ANUSHANADIKATLA/drug-delivery-to-the-brain-124040723
Nov 26, 2018 · Drug delivery directly to the brain interstitium has recently been markedly enhanced through the rational design of polymer-based drug delivery systems. Substantial progress will only come about, however, if continued vigorous research efforts to develop more therapeutic and less toxic drug molecules are paralleled by the aggressive pursuit of more effective mechanisms for delivering those drugs …
http://www.authorstream.com/Presentation/amol.sabale-1380346-brain-targeted-drug-delivery-system/
Apr 05, 2012 · CELLULAR BARRIERS TO DRUG DELIVERY TO CNS: The first and largest interface is the brain capillary endothelial cells that form the Blood brain barrier ( BBB). The second barrier is the Blood–cerebrospinal fluid barrier (BCSFB) .
https://www.nature.com/articles/s41467-019-13198-y
Nov 15, 2019 · Local drug delivery to brain tumors without unwanted release to cerebrospinal fluid (CSF) is important 11. Mechanical mismatch of rigid implantable devices from brain tissues …Author: Jongha Lee, Hye Rim Cho, Gi Doo Cha, Hyunseon Seo, Hyunseon Seo, Seunghyun Lee, Chul Kee Park, Jin W...
https://www.researchgate.net/publication/279408805_Brain_targeting_Drug_Delivery_System_A_Review
The most distressing fact about delivery of drugs to the CNS is the presence of blood brain barrier that have a tendency to impair the drug distribution and denotes the major impediment for the...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629063/
Apr 05, 2014 · The “systematic targeted drug delivery” or “whole-process targeting” is recognized as an effective brain tumor targeted drug delivery strategy which considers all the possible targets including barriers, microenvironment and cancer cells.Author: Xiaoli Wei, Xishan Chen, Man Ying, Weiyue Lu
https://www.nature.com/articles/nrd.2015.21
Jan 22, 2016 · Research in the past few decades has revealed that the BBB is not only a substantial barrier for drug delivery to the CNS but also a complex, dynamic interface that adapts to the needs of the CNS, responds to physiological changes…Author: William A. Banks
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